当前位置: X-MOL 学术Beilstein. J. Org. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Preparation and in situ use of unstable N-alkyl α-diazo-γ-butyrolactams in RhII-catalyzed X–H insertion reactions
Beilstein Journal of Organic Chemistry ( IF 2.7 ) Pub Date : 2020-04-02 , DOI: 10.3762/bjoc.16.55
Maria Eremeyeva , Daniil Zhukovsky , Dmitry Dar’in , Mikhail Krasavin

N-Alkyl α-diazo-γ-butyrolactams, previously found to be unstable and to undergo unproductive dimerization to bishydrazones, were successfully converted immediately to various X–H insertion products with alcohols, aromatic amines and thiols via an in situ RhII-catalyzed reaction. With aliphatic amines or unreactive, sterically hindered anilines, the reactions tended to yield enamine adducts.

中文翻译:

RhII催化的X–H插入反应中不稳定N-烷基α-重氮-γ-丁内酰胺的制备和原位使用

N-烷基α-重氮-γ-丁内酰胺以前被发现不稳定,并且无法进行二聚生成双hydr,已通过原位Rh II催化,立即与醇,芳族胺和硫醇成功转化为各种X–H插入产物。反应。与脂族胺或未反应的,空间受阻的苯胺相比,反应趋于产生烯胺加合物。
更新日期:2020-04-03
down
wechat
bug