The interfacial behavior of curcumin, a model anti-inflammatory drug was studied upon interaction with cetyl palmitate and 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine. Cetyl palmitate finds applications for topical delivery in nanostructured lipid carriers, while the phosphatidylcholine was used both as a component of the carrier and as a model membrane lipid. Here, surface pressure, thermodynamics, Brewster angle microscopy, molecular dynamics and polarization modulation infrared reflection-absorption spectroscopy were used to better our understanding of the interaction between the components of the delivery systems and, on the other hand, their interaction with biological membranes. Moreover, thermodynamics was used to analyze the effect of curcumin on the lipid systems and, in particular, on the model membranes. The results obtained indicate that mixtures of curcumin and cetyl palmitate form Langmuir films, while none of the two pure components does. This effect was interpreted in terms of formation of a complex between curcumin and the hydrophobic, water insoluble cetyl palmitate. The hydrophilic-hydrophobic balance of the complex allows its penetration into the monolayer and mixing with the phospholipid phase. This finding may be of interest for further design of phytolipids for drug delivery applications.

姜黄素（一种模型消炎药）与棕榈酸十六烷基酯和1,2-二油酰基-sn相互作用时的界面行为进行了研究-甘油-3-磷脂酰胆碱。棕榈酸十六烷基酯在纳米结构脂质载体中发现了局部递送的应用，而磷脂酰胆碱既用作载体的组分，又用作模型膜脂质。在这里，表面压力，热力学，布鲁斯特角显微镜，分子动力学和偏振调制红外反射吸收光谱法被用来更好地理解递送系统各组分之间的相互作用，以及它们与生物膜之间的相互作用。此外，热力学用于分析姜黄素对脂质系统，特别是模型膜的作用。获得的结果表明姜黄素和棕榈酸鲸蜡酯的混合物形成了朗缪尔膜，而两种纯组分均没有。姜黄素与疏水性，水不溶性棕榈酸十六烷基酯之间形成络合物可以解释这种作用。配合物的亲水-疏水平衡使其渗透到单层中并与磷脂相混合。该发现对于进一步设计用于药物递送应用的植物脂质可能是有意义的。