Abstract Encapsulation using nanoliposomes is widely recognized as an effective technique to protect sensitive bioactive compounds from adverse processing or gastrointestinal conditions. In this study, marine phospholipids (MPL) nanoliposomes containing β-carotene were prepared as novel carriers by thin-film evaporation method and their characteristics were compared with traditional egg phosphatidylcholine (EPC) nanoliposomes. Initially, the average size of nanoliposomes was in the range of 162.86–365.81 nm and MPL nanoliposomes showed lower sizes compared to EPC nanoliposomes. A good size distribution and homogeneous dispersion for MPL nanoliposomes was also observed. The highest encapsulation efficiency (EE) recorded for MPL nanoliposomes was 99.06% compared to 96.53% for EPC nanoliposomes. Both types of nanoliposomes were able to inhibit lipid peroxidation but the highest inhibition was recorded for MPL nanoliposomes (42.9%) and the lowest (10.26%) for their EPC counterparts. Overall, MPL nanoliposomes showed higher stability at 4 °C for 70 days. Therefore, MPL can be explored for production of nanoliposomal systems as carriers for delivery of sensitive bioactive compounds in the food industry.

中文翻译：

---

加载β-胡萝卜素的海洋和卵磷脂纳米脂质体的比较

摘要 使用纳米脂质体封装被广泛认为是一种有效的技术，可以保护敏感的生物活性化合物免受不利加工或胃肠道状况的影响。本研究采用薄膜蒸发法制备了含有β-胡萝卜素的海洋磷脂（MPL）纳米脂质体作为新型载体，并将其特性与传统的卵磷脂（EPC）纳米脂质体进行了比较。最初，纳米脂质体的平均尺寸在 162.86-365.81 nm 的范围内，与 EPC 纳米脂质体相比，MPL 纳米脂质体的尺寸较小。还观察到 MPL 纳米脂质体的良好尺寸分布和均匀分散。MPL 纳米脂质体记录的最高封装效率 (EE) 为 99.06%，而 EPC 纳米脂质体为 96.53%。两种类型的纳米脂质体都能够抑制脂质过氧化，但 MPL 纳米脂质体的抑制作用最高（42.9%），EPC 纳米脂质体的抑制作用最低（10.26%）。总体而言，MPL 纳米脂质体在 4°C 下 70 天显示出更高的稳定性。因此，可以探索 MPL 用于生产纳米脂质体系统，作为在食品工业中递送敏感生物活性化合物的载体。