Microbial production of fatty acids and derivatives from non-edible biomass has attracted much attention as an alternative to their production from plant oils and animal fats. Fatty acids and some of their derivatives are ubiquitous metabolites synthesized for membrane biosynthesis and other metabolic purposes in microorganisms. These compounds, however, are rarely produced beyond cellular demands, frequently resulting in low titers even after metabolic engineering. Recently, more advanced metabolic engineering strategies including systems metabolic engineering allowed improved production of fatty acids and their derivatives by employing non-oleaginous and oleaginous microorganisms. Here, we review metabolic engineering strategies developed for the production of fatty acids and derivative chemicals by non-oleaginous and oleaginous microorganisms in recent years.

中文翻译：

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微生物生产脂肪酸和衍生化学品。

从食用生物质中微生物生产脂肪酸及其衍生物已成为备受关注的植物油和动物脂肪替代品。脂肪酸及其某些衍生物是普遍存在的代谢产物，用于微生物的膜生物合成和其他代谢目的。但是，这些化合物很少会超出细胞需求而产生，即使在代谢工程后也经常导致滴度低。近来，更高级的代谢工程学策略，包括系统代谢工程学，允许通过使用非油质和油质微生物改善脂肪酸及其衍生物的生产。这里，