BACKGROUND Suicide risk is high in first episode schizophrenia. Little data are available in young individuals at Ultra-High Risk (UHR) of psychosis. Purposes of the study were: (1) to assess prevalence and incidence rates of suicide attempts, suicidal ideation, and completed suicide in UHR individuals compared with First Episode Psychosis (FEP) and non-FEP/UHR help-seeking peers at baseline and over a 24-month follow-up time, and (2) to explore any association of suicidal ideation with other psychopathological parameters at baseline. METHODS 273 young people (13-35 years) were evaluated with the Comprehensive Assessment of At-Risk Mental States (CAARMS), the Beck Depression Inventory - II Edition (BDI), and the World Health Organization Quality Of Life scale - Brief version (WHOQOL-BREF). The BDI item 9 cut-off score of ≥1 dichotomized the presence/absence of suicidal ideation. RESULTS UHR individuals showed more severe suicidal ideation and a higher percentage of individuals with a history of attempted suicide than FEP and non-UHR/FEP samples, and a higher 2-year incidence rate of suicide attempts than non-UHR/FEP subjects. No inter-group differences in incidence rates of completed suicide were found. In the UHR group, suicidal ideation was associated with BDI-II and CAARMS "Anhedonia" scores, and showed a negative correlation with all WHOQOL-BREF scores. CONCLUSIONS Suicidal ideation is frequent in UHR subjects, supporting the routine monitoring of suicide risk in people at risk of psychosis. Suicide risk is correlated with severity of depression and anhedonia, and with a poorer quality of life.

中文翻译：

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处于精神病超高风险 (UHR) 的年轻人的自杀风险：一项为期 2 年的纵向研究结果

背景 首发精神分裂症的自杀风险很高。具有超高风险 (UHR) 精神病的年轻人的数据很少。该研究的目的是：(1) 评估 UHR 个体与基线及以上首次发作精神病 (FEP) 和非 FEP/UHR 寻求帮助的同龄人相比，自杀未遂、自杀意念和完成自杀的流行率和发生率24 个月的随访时间，以及 (2) 在基线时探索自杀意念与其他精神病理学参数之间的任何关联。方法 273 名年轻人（13-35 岁）接受了风险心理状态综合评估（CAARMS）、贝克抑郁量表 - II 版（BDI）和世界卫生组织生活质量量表 - 简要版（ WHOQOL-BREF）。BDI 项目 9 的分界点分数≥1 分为存在/不存在自杀意念。结果 与 FEP 和非 UHR/FEP 样本相比，UHR 个体表现出更严重的自杀意念和更高比例的有自杀未遂史的个体，以及比非 UHR/FEP 受试者更高的 2 年自杀未遂发生率。未发现完成自杀发生率的组间差异。在 UHR 组中，自杀意念与 BDI-II 和 CAARMS“快感缺失”评分相关，并与所有 WHOQOL-BREF 评分呈负相关。结论 自杀意念在 UHR 受试者中很常见，支持对有精神病风险的人的自杀风险进行常规监测。自杀风险与抑郁症和快感缺乏的严重程度以及较差的生活质量相关。