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Recent genetic advances in innate immunity of psoriatic arthritis.
Clinical Immunology ( IF 8.6 ) Pub Date : 2020-04-02 , DOI: 10.1016/j.clim.2020.108405
Grace Hile 1 , J Michelle Kahlenberg 2 , Johann E Gudjonsson 1
Affiliation  

Psoriatic arthritis (PsA) is a heterogeneous disease that affects multiple organ systems including the peripheral and axial joints, entheses and nails. PsA is associated with significant comorbidities including cardiovascular, metabolic, and psychiatric diseases. The pathogenesis of PsA is complex and involves genetic, immunologic and environmental factors. Recent evidence suggests the heritability for PsA to be stronger and distinct from that of PsC. Prominent genes identified via GWAS for PsA include HLA-B/C, HLAB, IL12B, IL23R, TNP1, TRAF3IP3, and REL. We review the genetics of psoriatic arthritis and discuss the role of the innate immune system as important in the pathogenesis of PsA by focusing on key signaling pathways and cellular makeup. Understanding the candidate genes identified in PsA highlights pathways of critical importance to the pathogenesis of psoriatic disease including the key role of the innate immune response, mediated through IL-23/IL-17 axis, RANK and NFκB signaling pathways.

中文翻译:

银屑病关节炎先天免疫的最新遗传进展。

银屑病关节炎 (PsA) 是一种异质性疾病,影响多个器官系统,包括周围和轴向关节、附着点和指甲。PsA 与包括心血管、代谢和精神疾病在内的重大合并症有关。PsA的发病机制复杂,涉及遗传、免疫和环境因素。最近的证据表明 PsA 的遗传力更强,并且与 PsC 不同。通过 GWAS 鉴定的 PsA 的显着基因包括 HLA-B/C、HLAB、IL12B、IL23R、TNP1、TRAF3IP3 和 REL。我们回顾了银屑病关节炎的遗传学,并通过关注关键信号通路和细胞构成来讨论先天免疫系统在 PsA 发病机制中的重要作用。
更新日期:2020-04-03
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