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Supercritical drying of thermoresponsive gels based on N-isopropylacrylamide
Journal of the Taiwan Institute of Chemical Engineers ( IF 5.7 ) Pub Date : 2020-04-02 , DOI: 10.1016/j.jtice.2020.03.004
Facundo Mattea , Ángel Martín

Thermoresponsive materials are of great interest for medicine, pharmacy and food industry. During the production of these materials they are often taken into their dry state, requiring gentle processes with minimum effect over their properties. In this study, supercritical drying process was used to obtain dry products from thermoresponsive N-Isopropylacrylamide based gels and compared to other typical drying processes like hot air- and freeze- drying. Depending on the method, different degrees of modification of the structure were observed, which have a significant influence on the final properties of the materials and on their rehydration. Results show that supercritical technology can be used to produce dry porous materials with less collapsed structure or modified properties than conventional or freeze drying techniques while keeping the thermoresponsive nature, which is translated into materials with higher porosity and surface area, and slightly improved swelling degree. Swelling kinetics results showed that materials dried by conventional drying displayed sigmoidal anomalous behavior, those dried by freeze-drying exhibited a two-stage anomalous behavior, and materials obtained by supercritical drying presented behaviors close to Fickian which is of great interest for further drug release applications.



中文翻译:

基于N-异丙基丙烯酰胺的热敏凝胶的超临界干燥

热敏材料在医药,制药和食品工业中引起了极大的兴趣。在生产这些材料的过程中,它们通常处于干燥状态,需要温和的过程,而对其性能的影响最小。在这项研究中,使用超临界干燥工艺从热敏性N-异丙基丙烯酰胺基凝胶中获得干燥产品,并将其与其他典型的干燥工艺(如热风干燥和冷冻干燥)进行比较。根据方法的不同,观察到不同程度的结构改性,这对材料的最终性能及其再水化有重大影响。结果表明,超临界技术可用于生产比常规或冷冻干燥技术具有更少塌陷结构或改性特性的干燥多孔材料,同时保持热响应性,这转化为具有更高孔隙率和表面积的材料,并且溶胀度略有改善。溶胀动力学结果表明,通过常规干燥干燥的材料表现出S形异常行为,通过冷冻干燥干燥的材料表现出两阶段异常行为,并且通过超临界干燥获得的材料表现出接近Fickian的行为,这对于进一步的药物释放应用非常感兴趣。

更新日期:2020-04-02
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