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Ultrasensitive monitoring of DNA damage associated with free radicals exposure using dynamic carbon nanotubes bridged interdigitated electrode array.
Environment International ( IF 11.8 ) Pub Date : 2020-04-02 , DOI: 10.1016/j.envint.2020.105672 Hui Zhao 1 , Misha Liu 2 , Tao Jiang 3 , Jinjin Xu 2 , Huirong Zhang 2 , Chaofan Yu 2 , Zipeng Liu 4 , Ying Wang 4 , Longhua Tang 3
Environment International ( IF 11.8 ) Pub Date : 2020-04-02 , DOI: 10.1016/j.envint.2020.105672 Hui Zhao 1 , Misha Liu 2 , Tao Jiang 3 , Jinjin Xu 2 , Huirong Zhang 2 , Chaofan Yu 2 , Zipeng Liu 4 , Ying Wang 4 , Longhua Tang 3
Affiliation
There are currently increasingly concerns over DNA damage related to free radicals due to their vital roles in human health, especially high-performance detection method. Herein, we report an ultra- sensitive monitoring of DNA damage associated with free radicals exposure using interdigitated electrode (IDE) array for the first time. The proposed IDE array was equipped with DNA-wrapped carbon nanotube-based bridges, which utilized the DNA damage mechanism due to the free radicals' attack and the efficient electrical detection nature of the interdigitated electrode. Experiments have been performed, and the results showed the device's capability for detecting DNA damage induced by multiple free radicals generated from different sources, including the Fenton reaction, UV radiation and cigarette smoke, showing the promising ability for DNA damage detection. In addition, the carbon nanotubes bridge-based interdigitated electrode sensor enabled different levels of sensing of DNA damage with great sensitivity and a wide detection range. It was illustrated that the ultrasensitive detection of free radicals generated from ultraviolet radiation (15 min - 125 min), cigarette smoke tar (1 μg/mL to 10 μg/mL) and Fenton reaction under different concentration of H2O2 (2.5 pM - 100 pM), have been detected successfully. Typically, the IDE array supports further performance improvement for the electrochemical detection in an ultrasensitive and high throughput route.
中文翻译:
使用动态碳纳米管跨接指状电极阵列,超灵敏地监测与自由基暴露相关的DNA损伤。
由于自由基在人类健康中的重要作用,尤其是高性能的检测方法,目前对与自由基有关的DNA损伤越来越关注。在此,我们首次报道了使用叉指电极(IDE)阵列对与自由基暴露相关的DNA损伤进行超灵敏监测。拟议的IDE阵列配备了基于DNA包裹的碳纳米管的桥,该桥利用了DNA损伤机制,这是由于自由基的攻击和叉指电极的高效电学检测性质。已经进行了实验,结果表明该设备能够检测由不同来源(包括Fenton反应,紫外线辐射和香烟烟雾)产生的多种自由基引起的DNA损伤。显示出有希望的DNA损伤检测能力。此外,基于碳纳米管桥的叉指式电极传感器能够以高灵敏度和宽广的检测范围对DNA损伤进行不同程度的检测。结果表明,在不同浓度的H2O2(2.5 pM-100 pM)下,紫外线(15 min-125 min),香烟焦油(1μg/ mL至10μg/ mL)和Fenton反应产生的自由基的超灵敏检测。 ),已成功检测到。通常,IDE阵列支持在超灵敏和高通量途径中进行电化学检测的进一步性能改进。结果表明,在不同浓度的H2O2(2.5 pM-100 pM)下,紫外线(15 min-125 min),香烟焦油(1μg/ mL至10μg/ mL)和Fenton反应产生的自由基的超灵敏检测。 ),已成功检测到。通常,IDE阵列支持在超灵敏和高通量途径中进行电化学检测的进一步性能改进。结果表明,在不同浓度的H2O2(2.5 pM-100 pM)下,紫外线(15 min-125 min),香烟焦油(1μg/ mL至10μg/ mL)和Fenton反应产生的自由基的超灵敏检测。 ),已成功检测到。通常,IDE阵列支持在超灵敏和高通量途径中进行电化学检测的进一步性能改进。
更新日期:2020-04-03
中文翻译:
使用动态碳纳米管跨接指状电极阵列,超灵敏地监测与自由基暴露相关的DNA损伤。
由于自由基在人类健康中的重要作用,尤其是高性能的检测方法,目前对与自由基有关的DNA损伤越来越关注。在此,我们首次报道了使用叉指电极(IDE)阵列对与自由基暴露相关的DNA损伤进行超灵敏监测。拟议的IDE阵列配备了基于DNA包裹的碳纳米管的桥,该桥利用了DNA损伤机制,这是由于自由基的攻击和叉指电极的高效电学检测性质。已经进行了实验,结果表明该设备能够检测由不同来源(包括Fenton反应,紫外线辐射和香烟烟雾)产生的多种自由基引起的DNA损伤。显示出有希望的DNA损伤检测能力。此外,基于碳纳米管桥的叉指式电极传感器能够以高灵敏度和宽广的检测范围对DNA损伤进行不同程度的检测。结果表明,在不同浓度的H2O2(2.5 pM-100 pM)下,紫外线(15 min-125 min),香烟焦油(1μg/ mL至10μg/ mL)和Fenton反应产生的自由基的超灵敏检测。 ),已成功检测到。通常,IDE阵列支持在超灵敏和高通量途径中进行电化学检测的进一步性能改进。结果表明,在不同浓度的H2O2(2.5 pM-100 pM)下,紫外线(15 min-125 min),香烟焦油(1μg/ mL至10μg/ mL)和Fenton反应产生的自由基的超灵敏检测。 ),已成功检测到。通常,IDE阵列支持在超灵敏和高通量途径中进行电化学检测的进一步性能改进。结果表明,在不同浓度的H2O2(2.5 pM-100 pM)下,紫外线(15 min-125 min),香烟焦油(1μg/ mL至10μg/ mL)和Fenton反应产生的自由基的超灵敏检测。 ),已成功检测到。通常,IDE阵列支持在超灵敏和高通量途径中进行电化学检测的进一步性能改进。