WD40-Repeat Protein 62 (WDR62) is required to maintain neural and glial cell populations during embryonic brain growth. Although elevated expression of WDR62 is frequently associated with several tumour types, potential effects of excess WDR62 on proliferative growth remain undefined. Here, we demonstrate that glia specific overexpression of WDR62 in Drosophila larval brains resulted in increased cell size, over-proliferation and increased brain volume, without overt disruption of tissue organization. We further demonstrate WDR62 promoted over-proliferation and brain overgrowth by activating AURKA and pAKT signalling to increase MYC function in glial cells. Together these data suggest WDR62 normally functions in the glial lineage to activate oncogenic signalling networks, promoting proliferation and brain overgrowth.

中文翻译：

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果蝇Wdr62的水平升高通过AURKA向AKT和MYC发出信号而促进神经胶质细胞的生长和增殖。

WD40-重复蛋白62（WDR62）在胚胎脑生长过程中需要维持神经和胶质细胞群体。尽管WDR62的高表达通常与几种肿瘤类型有关，但过量WDR62对增殖性生长的潜在影响仍然不确定。在这里，我们证明果蝇幼虫脑中神经胶质细胞特异性WDR62的过度表达导致细胞大小增加，过度增殖和脑容量增加，而没有明显破坏组织组织。我们进一步证明，WDR62通过激活AURKA和pAKT信号来增加神经胶质细胞中的MYC功能，从而促进过度增殖和脑过度生长。这些数据共同表明，WDR62通常在神经胶质谱系中起作用，以激活致癌信号网络，促进增殖和脑过度生长。