Bacteria are extremely adept at overcoming the effects of antibiotics through a variety of mechanisms. As a result, researchers are constantly searching for antibiotics with new mechanisms of action. Culp and coworkers recently utilized a phylogeny-guided approach to mine the genomes of Actinomycetes species for glycopeptides with novel targets. Their efforts yielded the identification of complestatin and corbomycin as antibiotics with a different target than other glycopeptides.

中文翻译：

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系统发育指导方法可产生具有独特作用的糖肽。

细菌非常擅长通过多种机制克服抗生素的作用。结果，研究人员一直在寻找具有新作用机制的抗生素。Culp和他的同事们最近采用了系统发育指导的方法来挖掘放线菌物种的基因组，寻找具有新靶标的糖肽。他们的努力使complestatin和corbomycin被鉴定为与其他糖肽具有不同靶标的抗生素。