Over the last decades, great effort has gone into developing new biosensor technologies for applications in different fields such as disease diagnosis and detection of pollutants in water and food. Global developments in robotic, IoT technologies and in healthcare sensors require new flexible sensor technologies that are low cost and built from sustainable and reusable or recyclable materials. One of the most promising technologies is based on the development of surface acoustic wave (SAW) flexible biosensors, which are highly reproducible, reliable and wirelessly controllable. This work presents for the first time a novel aluminum nitride (AlN)-based conformable SAW immunosensor fabricated on recyclable polyethylene naphthalate. We apply it to the detection of E.Coli using a faster and innovative functionalization method that exploit Protein-A/antibody affinity. A higher sensitivity (Limit of detection-LoD, 6.54*10⁵ CFU/ml) of the Lamb wave traveling on the polymeric device has been obtained in comparison with SAWs traveling on AlN on silicon substrate (LoD, 1.04*10⁶ CFU/ml). Implementation of a finite element method allowed for the estimation of the single E.Coli mass of approximately 9*10⁻¹³ g. This work demonstrates the high biosensing potential of flexible polymeric SAW devices for bacteria contamination control in food chain, water and smart packaging.

在过去的几十年中，人们在开发用于不同领域的新生物传感器技术方面付出了巨大的努力，例如疾病诊断以及水和食品中污染物的检测。机器人、物联网技术和医疗传感器的全球发展需要新的灵活传感器技术，这些技术成本低，由可持续、可重复使用或可回收的材料制成。最有前途的技术之一是基于表面声波 (SAW) 柔性生物传感器的开发，这种传感器具有高度可重复性、可靠性和无线可控性。这项工作首次提出了一种基于可回收聚萘二甲酸乙二醇酯的新型氮化铝 (AlN) 基适形 SAW 免疫传感器。我们将其应用于大肠杆菌的检测使用更快和创新的功能化方法，利用蛋白质-A/抗体亲和力。^{与在硅衬底上的 AlN 上传播的 SAW（LoD，1.04*10 6}  CFU/ml  ）相比，在聚合物器件上传播的 Lamb 波具有更高的灵敏度（检测限-LoD，6.54*10 ⁵ CFU/ml） ）。有限元方法的实施允许估计大约 9*10 ^-13  g的单个大肠杆菌质量。这项工作展示了柔性聚合物 SAW 设备在食品链、水和智能包装中的细菌污染控制方面的高生物传感潜力。