At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome. We review the organization of LADs and provide evidence of LAD heterogeneity from cell ensemble and single-cell data. LADs are typically repressive environments in the genome; nonetheless, we discuss findings of lamin interactions with regulatory elements of active genes, and the role lamins may play in genome regulation. We address the relationship between LADs and other genome organizers, and the involvement of LADs in laminopathies. The current data lay the basis for future studies on the significance of lamin-chromatin interactions in health and disease.

中文翻译：

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与椎板相关的领域：外围事务和内部事务

在核外围，染色质与核层通过核层相关域 (LAD) 的关联有助于基因组的功能组织。我们回顾了 LAD 的组织，并从细胞集合和单细胞数据中提供了 LAD 异质性的证据。LADs 通常是基因组中的抑制环境；尽管如此，我们讨论了核纤层蛋白与活性基因的调控元件相互作用的发现，以及核纤层蛋白在基因组调控中可能发挥的作用。我们解决了法援署与其他基因组组织者之间的关系，以及法援署在椎板病中的参与。目前的数据为未来研究核纤层蛋白-染色质相互作用在健康和疾病中的重要性奠定了基础。