当前位置: X-MOL 学术Inflammopharmacology › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Selenium and selenoproteins: it's role in regulation of inflammation.
Inflammopharmacology ( IF 5.8 ) Pub Date : 2020-03-06 , DOI: 10.1007/s10787-020-00690-x
Sneha Hariharan 1 , Selvakumar Dharmaraj 1
Affiliation  

Abstract

Selenium is an essential immunonutrient which holds the human’s metabolic activity with its chemical bonds. The organic forms of selenium naturally present in human body are selenocysteine and selenoproteins. These forms have a unique way of synthesis and translational coding. Selenoproteins act as antioxidant warriors for thyroid regulation, male-fertility enhancement, and anti-inflammatory actions. They also participate indirectly in the mechanism of wound healing as oxidative stress reducers. Glutathione peroxidase (GPX) is the major selenoprotein present in the human body, which assists in the control of excessive production of free radical at the site of inflammation. Other than GPX, other selenoproteins include selenoprotein-S that regulates the inflammatory cytokines and selenoprotein-P that serves as an inducer of homeostasis. Previously, reports were mainly focused on the cellular and molecular mechanism of wound healing with reference to various animal models and cell lines. In this review, the role of selenium and its possible routes in translational decoding of selenocysteine, synthesis of selenoproteins, systemic action of selenoproteins and their indirect assimilation in the process of wound healing are explained in detail. Some of the selenium containing compounds which can acts as cancer preventive and therapeutics are also discussed. These compounds directly or indirectly exhibit antioxidant properties which can sustain the intracellular redox status and these activities protect the healthy cells from reactive oxygen species induced oxidative damage. Although the review covers the importance of selenium/selenoproteins in wound healing process, still some unresolved mystery persists which may be resolved in near future.

Graphic abstract



中文翻译:

硒和硒蛋白:它在调节炎症中的作用。

摘要

硒是一种必需的免疫营养素,它通过其化学键保持人体的新陈代谢活动。人体中天然存在的有机形式的硒是硒代半胱氨酸和硒蛋白。这些形式具有独特的合成和翻译编码方式。硒蛋白充当甲状腺调节、男性生育能力增强和抗炎作用的抗氧化战士。它们还作为氧化应激减少剂间接参与伤口愈合的机制。谷胱甘肽过氧化物酶 (GPX) 是存在于人体内的主要硒蛋白,它有助于控制炎症部位过度产生自由基。除了 GPX,其他硒蛋白包括调节炎性细胞因子的硒蛋白-S 和作为体内平衡诱导剂的硒蛋白-P。之前,报告主要集中在参考各种动物模型和细胞系的伤口愈合的细胞和分子机制上。在这篇综述中,详细解释了硒在硒代半胱氨酸的翻译解码、硒蛋白的合成、硒蛋白的全身作用及其在伤口愈合过程中的间接同化中的作用及其可能的途径。还讨论了一些可以作为癌症预防和治疗剂的含硒化合物。这些化合物直接或间接表现出抗氧化特性,可以维持细胞内氧化还原状态,这些活性保护健康细胞免受活性氧诱导的氧化损伤。尽管该综述涵盖了硒/硒蛋白在伤口愈合过程中的重要性,

图形摘要

更新日期:2020-03-06
down
wechat
bug