With the development of -omics approaches, the scientific community is now submerged by a wealth of information that can be used to analyze various parameters: the degree of protein sequence conservation, protein 3D structures as well as RNA and protein expression levels in various benign and tumor tissues, during organism development or upon exposure to chemicals such as endocrine disrupters. However, if such information can be used to identify genes with potentially important biological function, additional studies are needed to deeply characterize their cellular function in model organisms. Here, we discuss the case of such a gene: ERH, encoding a highly conserved homodimeric protein found in unicellular eukaryotes, plants and metazoan, of yet unknown biological function, which might be linked to mRNA metabolism and that is emerging as important for cell migration and metastasis.

随着组学方法的发展，科学界现在被大量可用于分析各种参数的信息所淹没：蛋白质序列的保守程度，蛋白质3D结构以及各种良性和良性的RNA和蛋白质表达水平肿瘤组织，生物体发育过程中或暴露于化学物质（如内分泌干扰物）时。但是，如果此类信息可用于鉴定具有潜在重要生物学功能的基因，则需要进行其他研究来深入表征模型生物中其细胞功能。在这里，我们讨论这种基因的情况：ERH，其编码在单细胞真核生物，植物和后生动物中发现的高度保守的同型二聚体蛋白，其生物学功能尚不清楚，