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A New Phenolic Glycoside from Viburnum Melanocarpum Fruits and its α-Glucosidase Inhibitory Activity
Chemistry of Natural Compounds ( IF 0.8 ) Pub Date : 2020-03-01 , DOI: 10.1007/s10600-020-02998-0
Zi-Yang Zhao , Jia Chen , Jie Shen , Jian-Hua Shao , Xu-Hua Huang , Chun-Chao Zhao

A new phenolic glycoside 1, together with its enantiomer (2), was isolated from the ethanolic extract of Viburnum melanocarpum P. S. Hsu fruits by repeated column chromatography. Its structure was identified as (7R,8S)-guaiacylglycerol 4-O-β-D-(6-O-vanilloyl)glucopyranoside (1) by spectroscopic data (1H NMR, 13C NMR, HSQC, HMBC, and ORD) and chemical methods. In the intestinal α-glucosidase inhibitory activity test, compound 1 exhibited potent inhibitory activity with IC50 value of 10.04 μM in comparison with the positive control acarbose (IC50 16.37 μM).

中文翻译:

一种新的黑果荚膜酚苷及其α-葡萄糖苷酶抑制活性

通过重复柱层析从黑果荚膜 (Viburnum melanocarpum PS Hsu) 果实的乙醇提取物中分离出一种新的酚糖苷 1 及其对映体 (2)。其结构通过光谱数据(1H NMR、13C NMR、HSQC、HMBC 和 ORD)和化学分析鉴定为 (7R,8S)-愈创木脂酰甘油 4-O-β-D-(6-O-vanilloyl)glupyranoside (1)方法。在肠道α-葡萄糖苷酶抑制活性试验中,与阳性对照阿卡波糖(IC50 16.37 μM)相比,化合物1表现出强抑制活性,IC50值为10.04 μM。
更新日期:2020-03-01
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