Bac Coronary artery disease (CAD) is the leading cause of death worldwide and most commonly develops as a result of atherosclerosis. ANGPTL8 is a secreted adipokine that regulates lipid metabolism and is associated with cardiometabolic diseases, including type 2 diabetes and CAD. However, the association between circulating ANGPTL8 levels and CAD is inconsistent among studies and the mechanism by which ANGPTL8 contributes to CAD development remains poorly understood. Here we sought to evaluate the relationship between ANGPTL8 levels and endothelial dysfunction and adipose tissue inflammation in CAD patients. Concentrations of ANGPTL8, adiponectin, TNF-α, IL6, hsCRP, ICAM-1, and VCAM-1 were measured by ELISA in serum samples from 192 CAD patients diagnosed with stenosis > 50% in at least one coronary artery by angiography and 71 individuals with normal heart function. Serum ANGPTL8 levels were significantly higher in CAD patients compared to controls (83.84 ± 23.25 ng/mL vs. 50.45 ± 17.73; p < 0.001), independent of adjustment for age, sex, BMI, smoking and statin use. ANGPTL8 could also differentiate CAD patients from controls with 82.3% specificity and 81.4% sensitivity (p < 0.001). Adiponectin levels were lower in CAD patients, while ICAM-1, VCAM-1, TNF-α, IL6, and hsCRP levels were higher compared to non-CAD controls (all p < 0.001). ANGPTL8 levels were associated with BMI in controls and with BMI, TG, and ICAM-1 in CAD patients. The presence of elevated ANGPTL8 levels in CAD patients and independent association with TG and ICAM-1 suggest a possible role related to endothelial dysfunction in the pathogenesis of atherosclerosis.

中文翻译：

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ANGPTL8的较高循环水平与冠心病患者的体重指数，甘油三酸酯和内皮功能障碍有关。

Bac冠状动脉疾病（CAD）是全球主要的死亡原因，最常见的原因是动脉粥样硬化。ANGPTL8是一种分泌的脂肪因子，可调节脂质代谢，并与包括2型糖尿病和CAD在内的心脏代谢疾病有关。然而，在研究中循环的ANGPTL8水平与CAD之间的关联是不一致的，而ANGPTL8促进CAD发育的机制仍知之甚少。在这里，我们试图评估ANGPTL8水平与CAD患者的内皮功能障碍和脂肪组织炎症之间的关系。ELISA法测定了192例诊断为狭窄的CAD患者的血清样品中ANGPTL8，脂联素，TNF-α，IL6，hsCRP，ICAM-1和VCAM-1的浓度> 至少有50％的冠状动脉造影患者和71名正常心脏功能患者。与年龄，性别，BMI，吸烟和他汀类药物使用情况的调整无关，CAD患者的血清ANGPTL8水平明显高于对照组（83.84±23.25 ng / mL vs. 50.45±17.73； p <0.001）。ANGPTL8还可以以82.3％的特异性和81.4％的敏感性将CAD患者与对照组区别开来（p <0.001）。与非CAD对照相比，CAD患者的脂联素水平较低，而ICAM-1，VCAM-1，TNF-α，IL6和hsCRP水平较高（所有p <0.001）。ANGPTL8水平与对照组的BMI以及CAD患者的BMI，TG和ICAM-1相关。