Hydroxyapatite(HA) are widely used in the field of drug delivery, especially nano‐HA and porous HA. However, there are few reports on the use of inverse opal HA as drug carrier. In this paper, based on the colloidal crystal template prepared by polystyrene microsphere with the diameter of 380 ± 10 nm, inverse opal HA was prepared by template method as the drug sustained‐release carrier using different dispersants and ratio of template to precursor. The results indicated that when the ratio of template to precursor was 1 : 15 and the dispersant was a mixture of water and alcohol, the prepared inverse opal HA showed a complete ordered porous morphology with uniform pore spacing. In the drug delivery test of amoxicillin, drug loading and release properties of the inverse opal HA were significantly better than that of nano‐HA. Drug loading of the inverse opal HA was about 2.17 times than that of nano‐HA, and drug‐loading performance was also obviously improved. At the same time, sustained release ability of the inverse opal HA was better than that of nano‐HA when releasing amoxicillin. In the first 3 h, the cumulative release rate of amoxicillin in the inverse opal HA was less than 40%, much lower than about 60% of nano‐HA, significantly slowing down the drug release rate and showing good persistence. Therefore, the inverse opal HA as a drug carrier could also improve the sudden release effect of drugs and make the release rate of drugs gentler.

中文翻译：

---

反蛋白石羟基磷灰石的制备及药物传递性能

羟基磷灰石（HA）被广泛用于药物输送领域，尤其是纳米HA和多孔HA。但是，很少有关于使用反蛋白石HA作为药物载体的报道。本文以聚苯乙烯微球制备的胶体晶体模板为380±10nm，采用模板法制备了反蛋白石HA作为药物缓释载体，使用了不同的分散剂和模板与前体的比例。结果表明，当模板与前体的比例为1:15且分散剂为水和醇的混合物时，制备的反蛋白石HA显示出完整的有序的多孔形态，具有均匀的孔间距。在阿莫西林的药物递送测试中，反蛋白石HA的载药量和释放性能明显优于nano-HA。反向蛋白石HA的载药量是nano-HA的2.17倍，载药性能也得到明显改善。同时，当释放阿莫西林时，反蛋白石HA的持续释放能力要优于nano-HA。在最初的3小时内，阿莫西林在反蛋白石HA中的累积释放率小于40％，远低于nano-HA的约60％，这大大减慢了药物释放速度并显示出良好的持久性。因此，反蛋白石HA作为药物载体还可以提高药物的突然释放效果，使药物的释放速率更缓和。当释放阿莫西林时，反蛋白石HA的持续释放能力要优于nano-HA。在最初的3小时内，阿莫西林在反蛋白石HA中的累积释放率小于40％，远低于nano-HA的约60％，这大大减慢了药物释放速度并显示出良好的持久性。因此，反蛋白石HA作为药物载体还可以提高药物的突然释放效果，使药物的释放速率更缓和。当释放阿莫西林时，反蛋白石HA的持续释放能力要优于nano-HA。在最初的3小时内，阿莫西林在反蛋白石HA中的累积释放率小于40％，远低于nano-HA的约60％，这大大减慢了药物释放速度并显示出良好的持久性。因此，反蛋白石HA作为药物载体还可以提高药物的突然释放效果，使药物的释放速率更缓和。