In systemic sclerosis (SS c), a persistent tissue repair process leads to progressive fibrosis of the skin and internal organs. The role of mesenchymal stem cells (MSC s), which characteristically initiate and regulate tissue repair, has not been fully evaluated. We undertook this study to investigate whether dividing metakaryotic MSC s are present in SS c skin and to examine whether exposure to the disease microenvironment activates MSC s and leads to transdifferentiation.

中文翻译：

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间质干细胞的致病性激活是由系统性硬化症中的疾病微环境诱导的。

在系统性硬化症（SS c）中，持续的组织修复过程会导致皮肤和内脏器官进行性纤维化。间充质干细胞（MSC s）的特征启动和调节组织修复的作用尚未得到充分评估。我们进行了这项研究，以调查SS c皮肤中是否存在分裂的原核MSC，并检查暴露于疾病微环境是否能激活MSC并导致转分化。