Saturated benzene mimetics, 2‐oxabicyclo[2.1.1]hexanes, were synthesized by P. K. Mykhailiuk and co‐workers (DOI: 10.1002/anie.202000548). The cover picture shows a constellation of such a molecule, that was designed as a water‐soluble analogue of both bicyclo[1.1.1]pentanes and meta‐disubstituted benzenes. The key reaction in the synthesis is an iodocyclization. The obtained compounds are chemically and metabolically stable, and are ready for the direct use in medicinal chemistry projects.

中文翻译：

---

水溶性非经典苯模拟物

饱和苯模拟物2-氧杂双环[2.1.1]己烷由P. K. Mykhailiuk及其同事合成（DOI：10.1002 / anie.202000548）。封面图片显示了这样一个分子的构象，该构象被设计为双环[1.1.1]戊烷和间二取代苯的水溶性类似物 。合成中的关键反应是碘环化。所获得的化合物在化学和代谢上都是稳定的，并准备直接用于药物化学项目。