During pregnancy, substantial alterations in cerebral plasticity, vascular remodeling and neuronal growth occur in the maternal brain. We investigated whether concentrations of selected neurodiagnostic biomarkers in the cerebrospinal fluid of women with preeclampsia/HELLP syndrome differ from those in healthy controls using enzyme-linked immunosorbent assay technique. We found that tau protein concentrations (p = 0.016) and phospho-tau/tau ratio (p < 0.001) in cerebrospinal fluid were significantly lower in 39 preeclamptic women compared to 44 healthy controls during third trimester of pregnancy. Beta-amyloid(1-40)/(1-42) ratio was significantly higher in HELLP syndrome than in severe preeclampsia (8.49 + 2.73 vs. 4.71 + 1.65; p = 0.007). We conclude that beta-amyloid(1-40)/(1-42) ratio in cerebrospinal fluid can discriminate severe preeclampsia and HELLP syndrome. High beta-amyloid peptide and low tau protein concentrations are associated with impaired development of the materno-feto-placental unit and correlate with placental dysfunction.

中文翻译：

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严重先兆子痫和HELLP综合征的脑脊髓β淀粉样肽（1-40）和（1-42）-一项先导研究。

在怀孕期间，产妇大脑会发生大脑可塑性，血管重塑和神经元生长的实质性改变。我们使用酶联免疫吸附技术研究了先兆子痫/ HELLP综合征妇女的脑脊液中所选神经诊断生物标志物的浓度是否与健康对照组中的浓度不同。我们发现39名先兆子痫妇女的脑脊液中tau蛋白浓度（p = 0.016）和磷酸化tau / tau比（p <0.001）在妊娠中期三个月明显低于44个健康对照。HELLP综合征中的β-淀粉样蛋白（1-40）/（1-42）比率显着高于严重先兆子痫（8.49 + 2.73对4.71 + 1.65; p = 0.007）。我们得出的结论是，脑脊液中β-淀粉样蛋白（1-40）/（1-42）的比率可以区分严重的先兆子痫和HELLP综合征。高β-淀粉样蛋白肽和低tau蛋白浓度与胎儿-胎盘单位发育受损有关，并与胎盘功能障碍有关。