Magnesium and Mg-based alloys are promising biomaterials for orthopedic implants because of their degradability, osteogenic effects, and biocompatibility. However, the drawbacks of these materials include high hydrogen gas production, unexpected corrosion resistance, and insufficient mechanical strength duration. Surface modification can protect these biomaterials and induce osteogenesis. In this work, a SrHPO₄ coating was developed for our patented biodegradable Mg–Nd–Zn–Zr alloy (abbr. JDBM) through a chemical deposition method. The coating was characterized by in vitro immersion, ion release, and cytotoxicity tests, which showed a slower corrosion behavior and excellent cell viability. RNA sequencing of MC3T3E1 cells treated with SrHPO₄-coated JDBM ion release test extract showed increased Tlr4, followed by the activation of the downstream PI3K/Akt signaling pathway, causing proliferation and growth of pre-osteoblasts. An intramedullary nail (IMN) was implanted in a femoral fracture rat model. Mechanical test, radiological and histological analysis suggested that SrHPO₄-coated JDBM has superior mechanical properties, induces more bone formation, and decreases the degradation rate compared with uncoated JDBM and the administration of TLR4 inhibitor attenuated the new bone formation for fracture healing. SrHPO₄ is a promising coating for JDBM implants, particularly for long-bone fractures.

镁和镁基合金因其可降解性、成骨效应和生物相容性而成为用于骨科植入物的有前途的生物材料。然而，这些材料的缺点包括氢气产量高、出乎意料的耐腐蚀性和机械强度持续时间不足。表面改性可以保护这些生物材料并诱导成骨。在这项工作中，我们通过化学沉积方法为我们获得专利的可生物降解 Mg-Nd-Zn-Zr 合金（简称 JDBM）开发了 SrHPO _4涂层。该涂层通过体外浸入、离子释放和细胞毒性测试进行了表征，显示出较慢的腐蚀行为和优异的细胞活力。用 SrHPO _{4处理的 MC3T3E1 细胞的 RNA 测序}包被的 JDBM 离子释放测试提取物显示Tlr4增加，随后激活下游 PI3K/Akt 信号通路，导致前成骨细胞增殖和生长。在股骨骨折大鼠模型中植入髓内钉（IMN）。机械测试、放射学和组织学分析表明，与未涂层的 JDBM 相比，SrHPO ₄涂层的 JDBM 具有优异的机械性能，诱导更多的骨形成，并降低了降解率，并且 TLR4 抑制剂的施用减弱了骨折愈合的新骨形成。SrHPO ₄是一种很有前途的 JDBM 植入物涂层，特别是对于长骨骨折。