Perfluorooctanoic acid (PFOA) is a widely used synthetic industrial chemical which accumulates in ecosystems and organisms. Our study have investigated the neurobehavioral effects of PFOA and the alleviation effects of PFOA-induced neurotoxicity by blueberry anthocyanins (ANT) in Dugesia japonica. The planarians were exposed to PFOA and ANT for ten days. Researchs showed that exposure to PFOA affected locomotor behavior and ANT significantly alleviated the reduction in locomotion induced by PFOA. The regeneration of eyespots and auricles was suppressed by PFOA and was promoted by ANT. Following exposure to PFOA, acetylcholinesterase activity continually decreased and was unaffected in the ANT group, but was elevated after combined administration of PFOA and ANT. Oxidative DNA damage was found in planarians exposed to PFOA and was attenuated after administration of ANT by the alkaline comet assay. Concentrations of three neurotransmitters increased following exposure to PFOA and decreased after administration of ANT. Furthermore, ANT promoted and PFOA inhibited neuronal regeneration. DjotxA, DjotxB, DjFoxG, DjFoxD and Djnlg associated with neural processes were up-regulated following exposure to PFOA. Our findings indicate that PFOA is a neurotoxicant while ANT can attenuate these detrimental effects.

中文翻译：

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全氟辛酸的神经毒性和由于紫the中的蓝莓花色苷而导致的暴露后恢复。

全氟辛酸（PFOA）是一种广泛使用的合成工业化学品，它会积聚在生态系统和生物中。我们的研究已经调查了蓝莓花色苷（ANT）在日本痢疾中的PFOA的神经行为作用和对PFOA诱导的神经毒性的缓解作用。涡虫暴露于PFOA和ANT十天。研究表明，暴露于PFOA会影响运动行为，而ANT可以明显减轻PFOA诱导的运动减少。PFOA抑制了眼点和耳廓的再生，而ANT促进了眼点和耳廓的再生。暴露于PFOA后，乙酰胆碱酯酶活性持续下降且在ANT组中不受影响，但在联合使用PFOA和ANT后升高。在暴露于PFOA的平面动物中发现了氧化性DNA损伤，并且在通过碱彗星测定法施用ANT后被减轻了。暴露于PFOA后，三种神经递质的浓度增加，而施用ANT后，其浓度降低。此外，ANT促进和PFOA抑制神经元再生。暴露于PFOA后，与神经过程相关的DjotxA，DjotxB，DjFoxG，DjFoxD和Djnlg上调。我们的发现表明，PFOA是一种神经毒剂，而ANT可以减轻这些有害作用。暴露于PFOA后，与神经过程相关的DjFoxD和Djnlg上调。我们的发现表明，PFOA是一种神经毒剂，而ANT可以减轻这些有害作用。暴露于PFOA后，与神经过程相关的DjFoxD和Djnlg上调。我们的发现表明，PFOA是一种神经毒剂，而ANT可以减轻这些有害作用。