A novel hydroxy functionalized naphthalimide-based fluorescent probe (denoted SP2)was successfully designed and synthesized for monitoring of H2S in living cells and environmental. In particular, SP2 can detect the H2S without assistance of organic solvent or surfactant. When H2S is present, the azide group in SP2 was reduced to amine group, resulting in a turn-on fluorescence signal. This remarkable properties of SP2 enable its applications in monitoring ex/endogenous H2S in HepG-2 cells and hydrogen sulfide release in laboratories or chemical plants through visual recognition by optical color change. The probe displays highly selective and sensitive recognition to H2S, with a low detection limit of 50.8 nM. Futhermore, this work presents the possibility of using naphthalimide-based "logic gate" platform for monitoring H2S in biological and environmental samples.

中文翻译：

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基于羟基官能化的萘二甲酰亚胺的新型“开启”荧光探针，可作为视觉平台识别环境和活细胞中的H2S。

成功设计并合成了一种新型的羟基官能化萘二甲酰亚胺基荧光探针（表示为SP2），用于监测活细胞和环境中的H2S。特别是SP2无需有机溶剂或表面活性剂即可检测H2S。当存在H2S时，SP2中的叠氮基被还原为胺基，导致荧光信号开启。SP2的这一卓越性能使其可用于通过光学颜色变化的视觉识别来监控HepG-2细胞中的内源性H2S和实验室或化工厂中硫化氢的释放。该探针显示出对H2S的高度选择性和敏感性，检测限为50.8 nM。此外，这项工作提出了使用基于萘二甲酰亚胺的“逻辑门”的可能性