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The Immuno-Mass Spectrometry Chemical Microscope
Trends in Chemistry ( IF 15.7 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.trechm.2020.02.014
Dominic J. Hare , Olga Shimoni , David P. Bishop

Elemental mass spectrometry (MS) imaging has evolved beyond mapping biometals in tissue sections. The continually improving sensitivity and spatial resolution of chemical imaging technology has the potential to revolutionize immunohistochemistry (IHC). We explore how simple modifications to routine immunostaining protocols that integrate ‘immuno-MS imaging’ (iMSI) are making in situ quantitative protein mapping a reality.



中文翻译:

免疫质谱化学显微镜

元素质谱(MS)成像已经超越了在组织切片中标测生物金属的范围。化学成像技术的灵敏度和空间分辨率的不断提高,有可能彻底改变免疫组织化学(IHC)。我们探索如何简单地修改集成了“免疫MS成像”(iMSI)的常规免疫染色方案,从而使原位定量蛋白质图谱成为现实。

更新日期:2020-04-01
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