A simple NIR-II emitting water-soluble system has been developed and applied in vitro and in vivo. In vitro, the fluorophore quickly accumulated in 2D and 3D cell cultures and rapidly reached the tumor in rodents, showing high NIR-II contrast for up to 1 week. This very efficient probe possesses all the qualities necessary for translation to the clinic as well as for the development of NIR-II emitting materials.

中文翻译：

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水溶性氮杂-BODIPYs：生物相容性有机染料，可用于高对比度的体内NIR-II成像。

已经开发了一种简单的发射NIR-II的水溶性系统，并在体外和体内应用。在体外，荧光团在2D和3D细胞培养物中迅速积累，并在啮齿动物中迅速到达肿瘤，显示长达1周的高NIR-II对比度。这种非常有效的探针具有翻译到临床以及开发NIR-II发射材料所需的所有质量。