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Thermodynamic Cost, Speed, Fluctuations, and Error Reduction of Biological Copy Machines
The Journal of Physical Chemistry Letters ( IF 5.7 ) Pub Date : 2020-03-31 , DOI: 10.1021/acs.jpclett.0c00545
Yonghyun Song 1 , Changbong Hyeon 1
Affiliation  

Due to large fluctuations in cellular environments, transfer of information in biological processes without regulation is error-prone. The mechanistic details of error-reducing mechanisms in biological copying processes have been a subject of active research; however, how error reduction of a process is balanced with its thermodynamic cost and dynamical properties remain largely unexplored. Here, we study the error reducing strategies in light of the recently discovered thermodynamic uncertainty relation (TUR) that sets a physical bound to the cost-precision trade-off for dissipative processes. We found that the two representative copying processes, DNA replication by the exonuclease-deficient T7 DNA polymerase and mRNA translation by the E. coli ribosome, reduce the error rates to biologically acceptable levels while also optimizing the processes close to the physical limit dictated by TUR.

中文翻译:

生物复印机的热力学成本,速度,波动和减少错误

由于细胞环境的巨大波动,在没有调节的生物过程中传递信息容易出错。生物复制过程中减少错误的机制的机械细节一直是积极研究的主题。但是,如何减少过程中的错误与其热力学成本和动力学特性之间的平衡仍未得到充分探索。在这里,我们根据最近发现的热力学不确定性关系(TUR)研究了减少误差的策略,该关系为耗散过程的成本精确度取舍设置了物理限制。我们发现了两个代表性的复制过程,即核酸外切酶缺陷型T7 DNA聚合酶的DNA复制和大肠杆菌的mRNA翻译 核糖体,可将错误率降低至生物学上可接受的水平,同时还可将过程优化至接近TUR规定的物理极限。
更新日期:2020-04-24
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