### [Varghese et al. Page 1555][1] Trifluridine/tipiracil (FTD/TPI), an oral cytotoxic agent, has previously led to improved survival in patients with pretreated, refractory metastatic colorectal cancer. Varghese and colleagues conducted a phase I evaluation of the combination of FTD/TPI,

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### [Varghese等。[第1555页] [1]口服细胞毒剂三氟哌啶/替吡酯（FTD / TPI）先前已提高了患有预处理的难治性转移性结直肠癌患者的生存率。Varghese及其同事对FTD / TPI的组合进行了第一阶段的评估，