Cancer cachexia is a poorly understood metabolic consequence of cancer. During cachexia, different adipose depots demonstrate differential wasting rates. Animal models suggest adipose tissue may be a key driver of muscle wasting through fat–muscle crosstalk, but human studies in this area are lacking. We performed global gene expression profiling of visceral (VAT) and subcutaneous (SAT) adipose from weight stable and cachectic cancer patients and healthy controls.

中文翻译：

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脂肪库基因表达和 intelectin-1 在对癌症和恶病质的代谢反应中的作用。

癌症恶病质是一种鲜为人知的癌症代谢后果。在恶病质期间，不同的脂肪库表现出不同的消耗率。动物模型表明，脂肪组织可能是通过脂肪-肌肉串扰导致肌肉萎缩的关键驱动因素，但缺乏这方面的人体研究。我们对体重稳定和恶病质癌症患者和健康对照的内脏 (VAT) 和皮下 (SAT) 脂肪进行了全局基因表达谱分析。