Transient receptor potential vanilloid (TRPV) channels are part of the superfamily of TRP ion channels and play important roles in widespread physiological processes including both neuronal and non‐neuronal pathways. Various diseases such as skeletal abnormalities, chronic pain, and cancer are associated with dysfunction of a TRPV channel. In order to obtain full understanding of disease pathogenesis and create opportunities for therapeutic intervention, it is essential to unravel how these channels function at a molecular level. In the past decade, incredible progress has been made in biochemical sample preparation of large membrane proteins and structural biology techniques, including cryo‐electron microscopy. This has resulted in high resolution structures of all TRPV channels, which has provided novel insights into the molecular mechanisms of channel gating and regulation that will be summarized in this review.

中文翻译：

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瞬时受体电位香草通道的高分辨率结构：揭示功能多样的离子通道组。

瞬时受体电位香草酸（TRPV）通道是TRP离子通道超家族的一部分，并且在广泛的生理过程（包括神经元和非神经元途径）中发挥重要作用。各种疾病，例如骨骼异常，慢性疼痛和癌症，都与TRPV通道功能异常有关。为了全面了解疾病的发病机理并为治疗性干预创造机会，必须弄清这些通道在分子水平上的作用。在过去的十年中，大膜蛋白的生物化学样品制备和包括冷冻电子显微镜在内的结构生物学技术取得了令人难以置信的进步。这导致了所有TRPV通道的高分辨率结构，