This paper presents an implantable fluorescence system with a composite emission filter and fiber-coupled laser excitation. The composite structure of the short-pass interference filter and absorption filters exhibited a band-pass spectrum between 510 and 570 nm, which is close to green fluorescent protein (GFP) emission. A high-quality excitation light was achieved by utilizing a blue laser through a low-numerical-aperture optical fiber. This coupling method is beneficial in delivering a narrow spectrum and controllable irradiation light in a specific area to minimize auto-fluorescence from the tissue. The fabricated lensless system performance is experimentally validated by imaging emission. The proposed device is capable of perceiving fluorescence emission from microspheres and GFP noticeably.

中文翻译：

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具有带通复合发射滤波器和平行光纤耦合激光激发的针型成像传感器

本文提出了一种具有复合发射滤光片和光纤耦合激光激发的植入式荧光系统。短通干涉滤光片和吸收滤光片的复合结构表现出 510 到 570 nm 之间的带通光谱，接近绿色荧光蛋白 (GFP) 发射。通过低数值孔径光纤利用蓝色激光获得高质量的激发光。这种耦合方法有利于在特定区域提供窄光谱和可控的照射光，以最大限度地减少来自组织的自发荧光。制造的无透镜系统性能通过成像发射进行了实验验证。所提出的装置能够明显感知微球和 GFP 的荧光发射。