Abstract—In posttraumatic stress disorder (PTSD), the development of anxiety symptoms correlates with an increase in the content of noradrenaline and dopamine and a decrease in the content of serotonin in the limbic structures of the brain. Unfortunately, the character of changes in the level of monoamines in the brain stem structures such as the pons Varolii is not known, although it is damaged in patients with PTSD. The aim of the study was to determine the content of monoamine-neurotransmitters and their metabolites in the pons Varolii under the conditions of experimental PTSD. To reproduce the symptoms of PTSD, a predator stress model was used by exposing rats to the smell of a cat. The level of anxiety was determined using an elevated plus maze. High performance liquid chromatography was used to determine the concentrations of noradrenaline, dopamine, and the metabolite of dopamine, dihydroxyphenylacetic acid. It was found that under experimental PTSD, the content of noradrenaline in the pons Varolii decreased. At the same time, the content of dopamine and serotonin did not undergo significant changes. The content of noradrenaline negatively correlated with the anxiety index. In the pons Varolii, there were no changes in the level of monoamines typical of PTSD. In contrast to limbic structures, we observed a decrease in the level of noradrenaline with a constant level of other monoamines and their metabolites.

中文翻译：

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实验性创伤后应激障碍脑桥中单胺的含量

摘要-在创伤后应激障碍（PTSD）中，焦虑症状的发展与大脑边缘结构中去甲肾上腺素和多巴胺含量的增加以及5-羟色胺含量的减少有关。不幸的是，虽然PTSD患者受损，但脑干结构（例如pons Varolii）中单胺水平的变化特征尚不清楚。该研究的目的是确定在实验性PTSD条件下脑桥中单胺神经递质及其代谢产物的含量。为了重现PTSD的症状，使用捕食者应激模型，将大鼠暴露于猫的气味。使用高架迷宫确定焦虑程度。高效液相色谱法测定去甲肾上腺素，多巴胺，以及多巴胺的代谢产物二羟基苯基乙酸。发现在实验性PTSD下，脑桥中去甲肾上腺素的含量降低。同时，多巴胺和5-羟色胺的含量没有明显变化。去甲肾上腺素的含量与焦虑指数呈负相关。在pons Varolii中，PTSD典型的单胺水平没有变化。与边缘结构相反，我们观察到去甲肾上腺素水平下降，而其他单胺及其代谢产物水平保持不变。去甲肾上腺素的含量与焦虑指数呈负相关。在pons Varolii中，PTSD典型的单胺水平没有变化。与边缘结构相反，我们观察到去甲肾上腺素水平下降，而其他单胺及其代谢产物水平保持不变。去甲肾上腺素的含量与焦虑指数呈负相关。在pons Varolii中，PTSD典型的单胺水平没有变化。与边缘结构相反，我们观察到去甲肾上腺素水平下降，而其他单胺及其代谢产物水平保持不变。