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A Short Review of Biochemical Mechanisms in Iminodipropionitrile-Induced Movement Disorder
Neurochemical Journal ( IF 0.5 ) Pub Date : 2020-03-31 , DOI: 10.1134/s1819712420010031
Sara T. Alrashood , Mohamed S. Elrobh , Salman Alamery , Hamza A. Odeibat , Haseeb A. Khan

Abstract

Iminodipropionitrile (IDPN) is a synthetic nitrile that produces permanent behavioral syndrome characterized by repetitive head movements, circling and back walking in rodents. Other synthetic nitriles of industrial importance such as crotonitrile and allylnitrile are also able to produce similar motor deficits in experimental animals. Among these nitriles, IDPN has been recognized as a prototype nitrile to be used as a positive control for behavioral testing battery. Due to the well-defined behavioral deficits and their easy quantification, IDPN-induced behavioral syndrome is a preferential animal model to test the interaction of various agents with synthetic nitriles. The mechanism of IDPN-induced dyskinesia is multifactorial. This short review focuses on the roles of neurotransmitters, oxidative stress and inflammation in the pathogenesis of IDPN-induced neurotoxicity and behavioral deficits.


中文翻译:

丙二腈引起的运动障碍的生化机制简述

摘要

亚氨基丙腈(IDPN)是一种合成的腈,会产生永久性行为综合症,其特征是在啮齿动物中头部反复运动,盘旋和向后走。具有工业重要性的其他合成腈,如巴豆腈和烯丙基腈,也能够在实验动物中产生类似的运动缺陷。在这些腈中,IDPN被认为是原型腈,可用作行为测试电池的阳性对照。由于定义明确的行为缺陷及其易于量化,IDPN诱导的行为综合症是一种优先动物模型,用于测试各种试剂与合成腈的相互作用。IDPN引起的运动障碍的机制是多因素的。这篇简短的评论重点介绍了神经递质的作用,
更新日期:2020-03-31
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