Abstract—We used the radioligand binding method to study the neuroreceptor profile in the brain structures of subpopulations of outbred CD-1 mice that differ in stability of attention to environmental objects in the enriched closed plus maze test. In the prefrontal cortex of the subpopulation of mice with low attention to new objects, the density (B_max, fmol/mg of protein) of D2-dopamine receptors was 25% higher whereas the density of GABA_B-receptors was 34% lower compared to the mice with normal attention. We did not find any significant differences in the K_d and B_max indices in the binding with NMDA-receptors in the hippocampus and prefrontal cortex between the subpopulations of mice. We additionally examined mouse behavior in the enriched closed plus maze and elevated plus maze tests using correlation and factor analysis. The index of attention to objects of the enriched closed plus maze correlated and had significant factor load with the indices of exploratory activity, such as time in center and amount of rearing in the elevated plus maze but did not correlate with anxiety indices.

中文翻译：

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不同注意稳定性的CD-1小鼠亚群的神经受体特征和行为

摘要—我们使用放射性配体结合方法研究了远距离CD-1小鼠亚群脑结构中神经受体的分布情况，该小鼠在富集的密闭迷宫测试中对环境物体的注意力稳定性不同。在对新对象关注度较低的小鼠亚群的前额叶皮层中，D2-多巴胺受体的密度（B _max，fmol / mg蛋白）比高25％，而GABA _B受体的密度比其低34％。给予正常注意的小鼠。我们没有发现K _d和B _max有任何显着差异小鼠亚群之间与海马和前额叶皮层中NMDA受体结合的指数。我们还使用相关性和因子分析在富集封闭式迷宫和高架迷宫测试中检查了鼠标行为。注意力集中在密闭迷宫对象上的指标与探索活动的指标相关，并且具有显着的因素负荷，例如中心时间和高架迷宫中的饲养量，但与焦虑指标无关。