Abstract—The analgesic and neuroprotective activity of docosahexaenoic acid (DHA, 22:6 n-3) was studied in a model of rat chronic constriction injury of the sciatic nerve. We characterized the morphological and chemical state of the distal sciatic nerve segment and the activity of GFAP-positive astroglia and SP-ergic nerve fibers on the 7th and 28th day after the operation. It was found that DHA improves the morphological state of the sciatic nerve, prevents the degradation of the myelin basic protein and stabilizes the activity level of astroglia and SP-positive nerve fibers in the surface plates of the posterior horns of the spinal cord. In general, DHA has a complex effect on the course of the post-traumatic process in the central and peripheral nervous system, which indicates its high therapeutic potential.

中文翻译：

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坐骨神经慢性收缩损伤后二十二碳六烯酸在中枢和周围神经系统的神经保护活性

摘要—在大鼠坐骨神经慢性压迫性损伤模型中研究了二十二碳六烯酸（DHA，22：6 n-3）的镇痛和神经保护活性。我们在手术后的第7天和第28天表征了远端坐骨神经节的形态和化学状态以及GFAP阳性星形胶质细胞和SP能敏神经纤维的活性。发现DHA改善了脊髓后角表面中的坐骨神经的形态状态，防止了髓鞘碱性蛋白的降解并且稳定了星形胶质细胞和SP阳性神经纤维的活性水平。通常，DHA对中枢神经系统和周围神经系统的创伤后过程具有复杂的影响，这表明其具有很高的治疗潜力。