Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing
Science ( IF 56.9 ) Pub Date : 2020-03-31 , DOI: 10.1126/science.abb6936 Luca Ferretti 1 , Chris Wymant 1 , Michelle Kendall 1 , Lele Zhao 1 , Anel Nurtay 1 , Lucie Abeler-Dörner 1 , Michael Parker 2 , David Bonsall 1, 3 , Christophe Fraser 1, 4
Science ( IF 56.9 ) Pub Date : 2020-03-31 , DOI: 10.1126/science.abb6936 Luca Ferretti 1 , Chris Wymant 1 , Michelle Kendall 1 , Lele Zhao 1 , Anel Nurtay 1 , Lucie Abeler-Dörner 1 , Michael Parker 2 , David Bonsall 1, 3 , Christophe Fraser 1, 4
Affiliation
Instantaneous contact tracing New analyses indicate that severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is more infectious and less virulent than the earlier SARS-CoV-1, which emerged in China in 2002. Unfortunately, the current virus has greater epidemic potential because it is difficult to trace mild or presymptomatic infections. As no treatment is currently available, the only tools that we can currently deploy to stop the epidemic are contact tracing, social distancing, and quarantine, all of which are slow to implement. However imperfect the data, the current global emergency requires more timely interventions. Ferretti et al. explored the feasibility of protecting the population (that is, achieving transmission below the basic reproduction number) using isolation coupled with classical contact tracing by questionnaires versus algorithmic instantaneous contact tracing assisted by a mobile phone application. For prevention, the crucial information is understanding the relative contributions of different routes of transmission. A phone app could show how finite resources must be divided between different intervention strategies for the most effective control. Science, this issue p. eabb6936 Instantaneous contact tracing and notifications by mobile phone app could potentially stop the COVID-19 epidemic. INTRODUCTION Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), has clear potential for a long-lasting global pandemic, high fatality rates, and incapacitated health systems. Until vaccines are widely available, the only available infection prevention approaches are case isolation, contact tracing and quarantine, physical distancing, decontamination, and hygiene measures. To implement the right measures at the right time, it is of crucial importance to understand the routes and timings of transmission. RATIONALE We used key parameters of epidemic spread to estimate the contribution of different transmission routes with a renewal equation formulation, and analytically determined the speed and scale for effective identification and contact tracing required to stop the epidemic. RESULTS We developed a mathematical model for infectiousness to estimate the basic reproductive number R0 and to quantify the contribution of different transmission routes. To parameterize the model, we analyzed 40 well-characterized source-recipient pairs and estimated the distribution of generation times (time from infection to onward transmission). The distribution had a median of 5.0 days and standard deviation of 1.9 days. We used published parameters for the incubation time distribution (median 5.2 days) and the epidemic doubling time (5.0 days) from the early epidemic data in China. The model estimated R0 = 2.0 in the early stages of the epidemic in China. The contributions to R0 included 46% from presymptomatic individuals (before showing symptoms), 38% from symptomatic individuals, 10% from asymptomatic individuals (who never show symptoms), and 6% from environmentally mediated transmission via contamination. Results on the last two routes are speculative. According to these estimates, presymptomatic transmissions alone are almost sufficient to sustain epidemic growth. To estimate the requirements for successful contact tracing, we determined the combination of two key parameters needed to reduce R0 to less than 1: the proportion of cases who need to be isolated, and the proportion of their contacts who need to be quarantined. For a 3-day delay in notification assumed for manual contact tracing, no parameter combination leads to epidemic control. Immediate notification through a contact-tracing mobile phone app could, however, be sufficient to stop the epidemic if used by a sufficiently high proportion of the population. We propose an app, based on existing technology, that allows instant contact tracing. Proximity events between two phones running the app are recorded. Upon an individual’s COVID-19 diagnosis, contacts are instantly, automatically, and anonymously notified of their risk and asked to self-isolate. Practical and logistical factors (e.g., uptake, coverage, R0 in a given population) will determine whether an app is sufficient to control viral spread on its own, or whether additional measures to reduce R0 (e.g., physical distancing) are required. The performance of the app in scenarios with higher values of R0 can be explored at https://bdi-pathogens.shinyapps.io/covid-19-transmission-routes/. CONCLUSION Given the infectiousness of SARS-CoV-2 and the high proportion of transmissions from presymptomatic individuals, controlling the epidemic by manual contact tracing is infeasible. The use of a contact-tracing app that builds a memory of proximity contacts and immediately notifies contacts of positive cases would be sufficient to stop the epidemic if used by enough people, in particular when combined with other measures such as physical distancing. An intervention of this kind raises ethical questions regarding access, transparency, the protection and use of personal data, and the sharing of knowledge with other countries. Careful oversight by an inclusive advisory body is required. Instant contact tracing can reduce the proportion of cases that need to be isolated and contacts who need to be quarantined to achieve control of an epidemic. Subject A becomes symptomatic after having had contact with other people in different settings the day before. Contacts are notified and quarantined where needed. In the inset, the green area indicates the success rates needed to control an epidemic with R0 = 2 (i.e., negative growth rates after isolating cases and quarantining their contacts). The newly emergent human virus SARS-CoV-2 (severe acute respiratory syndrome–coronavirus 2) is resulting in high fatality rates and incapacitated health systems. Preventing further transmission is a priority. We analyzed key parameters of epidemic spread to estimate the contribution of different transmission routes and determine requirements for case isolation and contact tracing needed to stop the epidemic. Although SARS-CoV-2 is spreading too fast to be contained by manual contact tracing, it could be controlled if this process were faster, more efficient, and happened at scale. A contact-tracing app that builds a memory of proximity contacts and immediately notifies contacts of positive cases can achieve epidemic control if used by enough people. By targeting recommendations to only those at risk, epidemics could be contained without resorting to mass quarantines (“lockdowns”) that are harmful to society. We discuss the ethical requirements for an intervention of this kind.
更新日期：2020-03-31
京公网安备 11010802027423号