Cholesterol biosynthesis is a high-cost process and, therefore, tightly regulated by both transcriptional and posttranslational negative feedback mechanisms in response to the level of cellular cholesterol. Squalene monooxygenase (SM, also known as squalene epoxidase or SQLE) is a rate-limiting enzyme in the cholesterol biosynthetic pathway and catalyzes epoxidation of squalene....

中文翻译：

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关键的哺乳动物胆固醇合成酶角鲨烯单加氧酶通过其底物变构稳定[生物化学]

胆固醇的生物合成是一个高成本的过程，因此，响应于细胞胆固醇的水平，其转录和翻译后的负反馈机制均对其进行严格调节。角鲨烯单加氧酶（SM，也称为角鲨烯环氧酶或SQLE）是胆固醇生物合成途径中的限速酶，催化角鲨烯的环氧化。