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Computational design of closely related proteins that adopt two well-defined but structurally divergent folds [Biophysics and Computational Biology]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-03-31 Kathy Y. Wei, Danai Moschidi, Matthew J. Bick, Santrupti Nerli, Andrew C. McShan, Lauren P. Carter, Po-Ssu Huang, Daniel A. Fletcher, Nikolaos G. Sgourakis, Scott E. Boyken, David Baker
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-03-31 Kathy Y. Wei, Danai Moschidi, Matthew J. Bick, Santrupti Nerli, Andrew C. McShan, Lauren P. Carter, Po-Ssu Huang, Daniel A. Fletcher, Nikolaos G. Sgourakis, Scott E. Boyken, David Baker
The plasticity of naturally occurring protein structures, which can change shape considerably in response to changes in environmental conditions, is critical to biological function. While computational methods have been used for de novo design of proteins that fold to a single state with a deep free-energy minimum [P.-S. Huang, S....
中文翻译：
采用两个定义明确但结构上不同的折叠的紧密相关蛋白质的计算设计[生物物理学和计算生物学]
天然存在的蛋白质结构的可塑性可响应环境条件的变化而大大改变形状，这对生物学功能至关重要。虽然计算方法已用于从头设计蛋白质，但蛋白质折叠到单一状态时具有极低的自由能[P.-S.]。黄先生
更新日期：2020-03-31
中文翻译：
采用两个定义明确但结构上不同的折叠的紧密相关蛋白质的计算设计[生物物理学和计算生物学]
天然存在的蛋白质结构的可塑性可响应环境条件的变化而大大改变形状，这对生物学功能至关重要。虽然计算方法已用于从头设计蛋白质，但蛋白质折叠到单一状态时具有极低的自由能[P.-S.]。黄先生
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