AIMS As the glucose tolerance of patients with diabetes worsens, autonomic nervous system (ANS) function decreases. Only a few studies, using plasma glucose, have reported on this relationship in large general populations that include people with wide range of glycemia. This study aimed to examine correlates of ANS function with special reference to HbA1c which is more stable than plasma glucose among community residents. METHODS Spectral analysis was performed to assess heart rate variability (HRV) using 1-minute electrocardiogram RR interval data recordings from 7690 residents aged 35-79 years in Nagahama City, Japan. HRV parameters were log-transformed. Multiple regression analysis was performed using potential correlates. RESULTS lnLF decreased with age (regression coefficient, -0.025; P < 0.001), BMI (-0.010; P = 0.035), and HbA1c (-0.068; P = 0.036). lnHF decreased with age (-0.029; P < 0.001), BMI (-0.032; P < 0.001), and HbA1c (-0.173; P < 0.001). lnLF/HF increased with age (0.003; P = 0.002), BMI (0.023; P < 0.001), and HbA1c (0.105; P < 0.001). Women showed lower lnLF and lnLF/HF than men. Sleep quality assessed by the Pittsburgh Sleep Quality Index, smoking and drinking had almost no relation. CONCLUSIONS Although the associations were weak, age, BMI and HbA1c were inversely correlated with parasympathetic activity, while positively correlated with sympathetic activity among general residents.

中文翻译：

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长寿研究表明，一般人群的自主神经系统功能与HbA1c有关。

目的随着糖尿病患者对葡萄糖的耐受性恶化，自主神经系统（ANS）功能下降。只有少数使用血浆葡萄糖的研究报道了在包括血糖范围广泛的人群在内的广大普通人群中的这种关系。这项研究旨在检查ANS功能的相关性，并特别提及HbA1c，它比社区居民中的血糖稳定。方法采用频谱分析法评估了日本长滨市7690名年龄在35-79岁的居民的1分钟心电图RR间隔数据，以评估心率变异性（HRV）。对HRV参数进行对数转换。使用潜在的相关性进行多元回归分析。结果lnLF随着年龄的增长而降低（回归系数-0.025; P <0.001），BMI（-0.010; P = 0.035）和HbA1c（-0。068; P = 0.036）。lnHF随年龄下降（-0.029; P <0.001），BMI（-0.032; P <0.001）和HbA1c（-0.173; P <0.001）下降。lnLF / HF随着年龄增加（0.003; P = 0.002），BMI（0.023; P <0.001）和HbA1c（0.105; P <0.001）而增加。女性的lnLF和lnLF / HF低于男性。匹兹堡睡眠质量指数评估的睡眠质量与吸烟和饮酒几乎没有关系。结论尽管相关性较弱，但年龄，BMI和HbA1c与副交感活动呈负相关，而与一般居民的交感活动呈正相关。女性的lnLF和lnLF / HF低于男性。匹兹堡睡眠质量指数评估的睡眠质量与吸烟和饮酒几乎没有关系。结论尽管相关性较弱，但年龄，BMI和HbA1c与副交感活动呈负相关，而与一般居民的交感活动呈正相关。女性的lnLF和lnLF / HF低于男性。匹兹堡睡眠质量指数评估的睡眠质量与吸烟和饮酒几乎没有关系。结论尽管相关性较弱，但年龄，BMI和HbA1c与副交感活动呈负相关，而与一般居民的交感活动呈正相关。