当前位置: X-MOL 学术Eur. Polym. J. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
In-Vitro and In-Vivo Study of Superabsorbent PVA/Starch/g-C3N4/Ag@TiO2 NPs Hydrogel Membranes for Wound Dressing
European Polymer Journal ( IF 6 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.eurpolymj.2020.109650
Arooj Ahmed , Muhammad Bilal Khan Niazi , Zaib Jahan , Tahir Ahmad , Arshad Hussain , Erum Pervaiz , Hussnain Ahmed Janjua , Zakir Hussain

Abstract The present study was focused on the fabrication and characterization of polymeric wound dressings, composed of PVA and Starch. Graphitic carbon nitride (g-C3N4) was incorporated as a filler and Silver deposited-Titania nanoparticles (Ag@TiO2 NPs) as an antibacterial agent. The hydrogel membranes were fabricated by solution casting under ambient conditions. The prepared hydrogels were subjected to various characterizations techniques and obtained data demonstrated good compatibility among the constituents of the membranes. The antibacterial activity was investigated against Escherichia coli and Staphylococcus aureus. The maximum zone of inhibition achieved was 37.33 and 33.25 mm, respectively at the composition PVA/Starch/0.14GCN/0.7Ag@TiO2 NPs. Furthermore, swelling, moisture retention and water vapor transmission results demonstrated that hydrogels were capable of absorbing large volume of wound exudates. Porosity and oxygen permeability results have demonstrated that hydrogels membranes were breathable. Lastly, kinetics of drug release was performed by using various mathematical models where Higuchian model was found to be the best fit. Non-Fickian diffusion mechanism prevailed and a sustained and slow release of nanoparticles was observed. The complete healing was accomplished in seven days. The fabricated hydrogel membranes depicted better healing than conventional cotton gauze wound dressings. The prepared hydrogel membranes have demonstrated all the potential to be used as wound dressing for partial and full thickness excision wounds after complete biological characterization.

中文翻译:

用于伤口敷料的超吸收性 PVA/淀粉/g-C3N4/Ag@TiO2 NPs 水凝胶膜的体外和体内研究

摘要 本研究的重点是由 PVA 和淀粉组成的聚合物伤口敷料的制备和表征。石墨氮化碳(g-C3N4)作为填料加入,银沉积二氧化钛纳米颗粒(Ag@TiO2 NPs)作为抗菌剂。水凝胶膜是在环境条件下通过溶液浇铸制造的。制备的水凝胶经过各种表征技术,获得的数据表明膜成分之间具有良好的相容性。研究了对大肠杆菌和金黄色葡萄球菌的抗菌活性。在 PVA/淀粉/0.14GCN/0.7Ag@TiO2 NPs 组成下,实现的最大抑菌圈分别为 37.33 和 33.25 毫米。此外,肿胀,保湿和水蒸气传输结果表明,水凝胶能够吸收大量的伤口渗出液。孔隙率和透氧性结果表明水凝胶膜是透气的。最后,药物释放动力学通过使用各种数学模型进行,其中 Higuchiian 模型被认为是最合适的。非菲克扩散机制占主导地位,并观察到纳米粒子的持续和缓慢释放。完全医治在七日内完成。制造的水凝胶膜比传统的棉纱布伤口敷料具有更好的愈合能力。在完成生物学表征后,制备的水凝胶膜已证明可用作部分和全层切除伤口的伤口敷料。
更新日期:2020-05-01
down
wechat
bug