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EasieRR: An open‐source software for non‐invasive heart rate variability assessment
Methods in Ecology and Evolution ( IF 6.6 ) Pub Date : 2020-04-17 , DOI: 10.1111/2041-210x.13393
Jeppe Have Rasmussen 1, 2 , Katrina Rosenberger 3 , Jan Langbein 2
Affiliation  

  1. The assessment of heart rate (HR) and heart rate variability (HRV) based on electrocardiograms (ECG) is considered a good proxy for stress in a wide range of animal species. However, problems can occur e.g., when measuring ECG in ambulatory settings such as recording of unrestrained animals using non‐invasive devices. Artefacts caused by technical (i.e. bad electrode contact) or physiological (i.e. ectopic beats, non‐cardiac muscle potentials) sources are common and can disturb the ECG signal. As HRV analysis is highly sensitive to artefacts in the interbeat interval (RR‐interval) time series the process of visual inspection of the raw signal to detect and correct these is essential. Most of the commercially available software requires intensive training and extensive manual work to accomplish this task and/or is often not available to access for free.
  2. EasieRR is an open‐source, stand‐alone software optimized for analysing ECG in non‐restrained animals. The program allows a species‐specific analysis and calculation of recommended standard HRV parameters in both, the time‐ and the nonlinear domain (RMSSD, SDNN, SD1 and SD2).
  3. Visualization of data using Poincaré plots and tachograms of RR‐intervals eases the validation of correct heart cycle interval detection and minimizes manual work for the user. Automatically detected peaks can be manually corrected via deletion, correction of spurious detections or marking of undetected peaks.
  4. The HRV analysis can be exported using common formats (TXT, MAT). Figures can be plotted and exported in various formats (PDF, SVG, PNG, JPG, TIFF, EMF and EPS).
  5. Included in EasieRR is the possibility for synchronization of ECG data with video in order to link cardiac responses to specific behavioural responses.


中文翻译:

EasieRR:一种用于无创心率变异性评估的开源软件

  1. 基于心电图(ECG)的心率(HR)和心率变异性(HRV)评估被认为是多种动物应激的良好替代。但是,例如在非卧床环境中测量ECG时,可能会出现问题,例如使用无创设备记录不受约束的动物。由技术性(即电极接触不良)或生理性(即异位搏动,非心肌肌肉电位)来源引起的伪影很常见,并且会干扰ECG信号。由于HRV分析对节拍间隔(RR-interval)时间序列中的伪影高度敏感,因此目视检查原始信号以检测和纠正这些错误的过程至关重要。
  2. EasieRR是一款开放源代码的独立软件,经过优化,可分析非拘束动物的ECG。该程序允许在时域和非线性域(RMSSD,SDNN,SD1和SD2)中对特定的标准HRV参数进行物种特定的分析和计算。
  3. 使用Poincaré图和RR间隔的轮速图对数据进行可视化可简化对正确的心动周期间隔检测的验证,并最大程度地减少了用户的人工工作。可以通过删除,错误检测的校正或未检测到的峰的标记来手动校正自动检测到的峰。
  4. 可以使用常见格式(TXT,MAT)导出HRV分析。可以以各种格式(PDF,SVG,PNG,JPG,TIFF,EMF和EPS)绘制和导出图形。
  5. EasieRR中包括ECG数据与视频同步的可能性,以便将心脏反应与特定行为反应联系起来。
更新日期:2020-04-17
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