Several cellular processes rely on a cohort of dedicated proteins that manage tubulation, fission, and fusion of membranes. A notably large number of them belong to the dynamin superfamily of proteins. Among them is the evolutionarily conserved group of ATP‐binding Eps15‐homology domain‐containing proteins (EHDs). In the two decades since their discovery, EHDs have been linked to a range of cellular processes that require remodeling or maintenance of specific membrane shapes such as during endocytic recycling, caveolar biogenesis, ciliogenesis, formation of T‐tubules in skeletal muscles, and membrane resealing after rupture. Recent work has shed light on their structure and the unique attributes they possess in linking ATP hydrolysis to membrane remodeling. This review summarizes some of these recent developments and reconciles intrinsic protein functions to their cellular roles.

中文翻译：

---

ATP结合Eps15同源域蛋白的细胞功能和内在属性。

几种细胞过程依赖于专门的蛋白质组，这些蛋白质管理着管的形成，裂变和融合。它们中的很大一部分属于蛋白质的动力蛋白超家族。其中包括进化上保守的ATP结合Eps15同源域蛋白（EHDs）。自发现以来，在过去的二十年中，EHD已与一系列细胞过程联系在一起，这些过程需要重塑或维持特定的膜形状，例如在内吞循环，海绵体生物发生，纤毛生成，骨骼肌T管形成和膜重封过程中破裂后。最近的工作揭示了它们的结构以及它们在将ATP水解与膜重塑联系起来方面所具有的独特属性。