In the present study, we use a carbazole‐functionalized ligand 4,4′‐(9H ‐carbazole‐2,7‐diyl)dibenzoic acid (H₂cdda) as the organic linker to react with Tb(NO₃)₃·6H₂O to afford a novel coordination polymer, whose chemical formula is [Tb₄(cdda)₆(H₂O)₄](DMF) (1 ). Because of its high emission intensity and uncoordinated N donor sites on its framework, 1 was studied as the sensor for Cu²⁺ ions, which showed high sensitivity and selectivity. The luminescence of 1 could be almost completely quenched in a solution of N ,N ‐dimethylformamide (DMF) with a detection limit of 10⁻⁶ mol/L and a K _sv (quenching coefficient of the metal ion) of 2,021.8 M⁻¹. Furthermore, the protective effect of the compound on Alzheimer's disease was evaluated. First, the inflammatory response in the neurons was determined via revere‐transcriptase polymerase chain reaction, as reflected by the changes in nf‐κb and akt relative expressions. Then, the amount of inflammatory cytokines was evaluated by enzyme‐linked immunosorbent assay.

中文翻译：

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基于Tb（III）的配位聚合物，可通过减少炎症反应和炎症细胞因子的释放来检测Cu（II）离子并治疗阿尔茨海默氏病

在本研究中，我们使用咔唑官能化的配体4,4'-（9 H-咔唑-2,7-二基）二苯甲酸（H ₂ cdda）作为有机连接基，与Tb（NO ₃）₃ · 6H ₂ O，得到新颖的配位聚合物，其化学式为[Tb ₄（cdda）₆（H ₂ O）₄ ]（DMF）（1）。由于其较高的发射强度和骨架上不协调的N供体位点，人们对1作为Cu ²⁺离子的传感器进行了研究，它具有很高的灵敏度和选择性。1的发光可以在N，N-二甲基甲酰胺（DMF）溶液中几乎完全淬灭，检测极限为10 ^-6 mol / L，K _sv（金属离子的猝灭系数）为2,021.8 M ^-1。此外，评估了该化合物对阿尔茨海默氏病的保护作用。首先，神经元的炎症反应是通过revere-transcriptase聚合酶链反应确定的，反映在nf-κb和akt相对表达的变化上。然后，通过酶联免疫吸附试验评估炎性细胞因子的量。