Serum concentrations of Anti-Müllerian hormone (AMH) and Inhibin B were used to assess potential fertility in survivors of childhood haematopoietic stem cell transplantation (HSCT) after three chemotherapy-conditioning regimens of differing intensity. Of 428 patients transplanted between 1990-2012 for leukaemia and immunodeficiency 121 surviving >1 year after a single HSCT were recruited. Group A had a treosulfan-based regimen (low-toxicity); Group B had fludarabine/melphalan (Flu-Mel) (reduced-intensity) and Group C had busulphan/cyclophosphamide (Bu-Cy) (myelo-ablative). Mean age at HSCT and follow-up and length of follow-up were 3.6, 11.8 and 9.9 years. Mean AMH standard deviation scores (SDS) were significantly higher in Group A (-1.047) and Group B (-1.255) than Group C (-1.543), suggesting less ovarian reserve impairment after treosulfan and Flu-Mel than after Bu-Cy. Mean serum AMH concentration was significantly better with treosulfan (>1.0 μg/l) than with Flu-Mel or Bu-Cy. In males, mean Inhibin B SDS was significantly higher in Group A (-0.506) than in Group B (-2.53) and Group C (-1.23) with the Flu-Mel group suffering greatest impairment. In conclusion, a treosulfan-based regimen confers a more favourable outlook for gonadal reserve than Flu-Mel or Bu-Cy in both sexes. Higher values of Inhibin B after Bu-Cy than after Flu-Mel may reflect recovery over time.

中文翻译：

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儿童干细胞移植后的抗苗勒管激素和抑制素B：清髓性，降低强度和基于硫代砜的化疗方案的比较。

在三种强度不同的化疗条件下，使用抗苗勒管激素（AMH）和抑制素B的血清浓度评估儿童造血干细胞移植（HSCT）幸存者的潜在生育能力。在1990年至2012年之间因白血病和免疫缺陷而移植的428名患者中，有121名在单次HSCT后存活> 1年存活。A组采用基于硫磺的方案（低毒）；B组具有氟达拉滨/美法仑（Flu-Mel）（强度降低），C组具有丁苯丙氨酸/环磷酰胺（Bu-Cy）（清髓性）。HSCT和随访的平均年龄以及随访时间分别为3.6、11.8和9.9岁。A组（-1.047）和B组（-1.255）的平均AMH标准差评分（SDS）明显高于C组（-1.543），这表明，在使用硫丹和Flu-Mel后，卵巢储备损害要比在Bu-Cy后少。硫代硫丹（> 1.0μg/ l）的平均血清AMH浓度明显优于Flu-Mel或Bu-Cy。在男性中，A组（-0.506）的平均抑制素B SDS显着高于B组（-2.53）和C组（-1.23），其中Flu-Mel组遭受的损害最大。总之，基于二硫的治疗方案在两性方面都比Flu-Mel或Bu-Cy更有利于性腺储备。Bu-Cy后的抑制素B值高于Flu-Mel后的抑制素B值，可能反映了随着时间的恢复。23）Flu-Mel组受损最大。总之，基于二硫的治疗方案在两性方面都比Flu-Mel或Bu-Cy提供更好的性腺储备前景。Bu-Cy后的抑制素B值高于Flu-Mel后的抑制素B值，可能反映了随着时间的恢复。23）Flu-Mel组遭受的损害最大。总之，基于二硫Flu的治疗方案在两性方面都比Flu-Mel或Bu-Cy更有利于性腺储备。Bu-Cy后的抑制素B值高于Flu-Mel后的抑制素B值，可能反映了随着时间的恢复。