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Organic Phosphorous and Calcium Source Induce the Synthesis of Yolk-Shell Structured Microspheres of Calcium Phosphate with High-Specific Surface Area: Application in HEL Adsorption
Nanoscale Research Letters ( IF 5.418 ) Pub Date : 2020-03-30 , DOI: 10.1186/s11671-020-03298-w
Xianshuo Cao , Guizhen Wang , Kai Wang , Lan Guo , Yang Cao , Xianying Cao , Yong Yang

Abstract

Yolk-shell-structured calcium phosphate microspheres have a great potential for medical applications due to their excellent physicochemical properties and biocompatibility. However, developing a yolk-shell-structured calcium phosphate with high adsorption capability remains a challenge. Herein, a porous yolk-shell-structured microsphere (ATP-CG) of calcium phosphate with high-specific surface area [SBET = 143 m2 g−1, which is approximately three times as high as that of ATP-CL microspheres synthesized by replacing calcium source with calcium l-lactate pentahydrate (CL)] was successfully synthesized by using adenosine 5'-triphosphate disodium salt (ATP) as the phosphorous source and calcium gluconate monohydrate (CG) as calcium source through a self-templating approache. The influences of molar ratio of Ca to P (Ca/P), hydrothermal temperature, and time on the morphology of ATP-CG microspheres were also investigated. It is found that the organic calcium source and organic phosphorous source play a vital role in the formation of yolk-shell structure. Furthermore, a batch of adsorption experiments were investigated to illuminate the adsorption mechanism of two kinds of yolk-shell-structured microspheres synthesized with different calcium sources. The results show that the adsorption capacity of ATP-CG microspheres (332 ± 36 mg/g) is about twice higher than that of ATP-CL microspheres (176 ± 33 mg/g). Moreover, the higher-specific surface area caused by the calcium source and unique surface chemical properties for ATP-CG microspheres play an important role in the improvement of HEL adsorption capability. The study indicates that the as-prepared yolk-shell-structured microsphere is promising for application in drug delivery fields and provides an effective approach for improving drug adsorption capability.



中文翻译:

有机磷和钙源诱导高比表面积磷酸钙卵黄壳结构微球的合成:在HEL吸附中的应用

摘要

卵黄壳结构的磷酸钙微球由于其优异的理化性质和生物相容性,在医学上具有巨大的潜力。然而,开发具有高吸附能力的卵黄壳结构的磷酸钙仍然是一个挑战。在此,具有高比表面积[ S BET = 143 m 2 g -1的磷酸钙的卵黄壳结构微球(ATP-CG),其约为合成的ATP-CL微球的三倍。通过用钙l代替钙源通过自模板方法成功地使用腺苷5'-三磷酸二钠盐(ATP)作为磷源和葡萄糖酸钙一水合物(CG)作为钙源成功合成了[-乳酸五水合物(CL)]。还研究了钙磷摩尔比(Ca / P),水热温度和时间对ATP-CG微球形态的影响。发现有机钙源和有机磷源在蛋黄壳结构的形成中起着至关重要的作用。此外,还进行了一批吸附实验,阐明了两种钙源不同的卵黄壳结构微球的吸附机理。结果表明,ATP-CG微球(332±36 mg / g)的吸附能力是ATP-CL微球(176±33 mg / g)的约两倍。此外,由钙源引起的较高的比表面积和ATP-CG微球的独特表面化学性质在提高HEL吸附能力方面起着重要作用。研究表明,所制备的卵黄壳结构微球有望在药物输送领域中应用,并为提高药物吸附能力提供了有效途径。

更新日期:2020-03-30
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