Prevalence of other autoimmune diseases in polyglandular autoimmune syndromes type II and III.,Journal of Endocrinological Investigation

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Prevalence of other autoimmune diseases in polyglandular autoimmune syndromes type II and III.
Journal of Endocrinological Investigation ( IF 5.4 ) Pub Date : 2020-08-17 , DOI: 10.1007/s40618-020-01229-1
G Pham-Dobor _{1,

2} , L Hanák ₃ , P Hegyi _{1,

3} , K Márta ₃ , A Párniczky _{3,

4} , M Gergics _{1,

2} , P Sarlós ₁ , B Erőss _{1,

3} , E Mezősi _{1,

2}

Affiliation

Purpose

Polyglandular autoimmune syndromes (PAS) are complex, heterogeneous disorders in which various autoimmune diseases can occur, affecting both endocrine and non-endocrine organs. In this meta-analysis, the prevalence of associated autoimmune disorders was investigated in PAS II and III.

Methods

A comprehensive search in MEDLINE and Embase databases identified 479 studies with the keywords of PAS II and PAS III. 18 records containing a total of 1312 patients fulfilled our inclusion criteria (original studies reporting at least 10 cases and containing the combination of other autoimmune disorders) and were selected for further analysis. A meta-analysis of prevalence was performed using the random-effects model with the calculation of 95% confidence intervals (CI). Results of each meta-analysis were displayed graphically using forest plots.

Results

Distinction between PAS II and PAS III was made in 842 cases, of which 177 and 665 were PAS II and III (21.1 vs 78.9%), respectively. The prevalence of Hashimoto’s thyroiditis was significantly higher than that of Graves’s disease (39% [95% CI 17–65%] vs. 4% [95% CI 0–10%], respectively; p = 0.001). In PAS II, Addison’s disease (AD) coexisted with AITDs, T1DM or the combination of these conditions in 65, 18 and 10% of cases, respectively. In addition, one other endocrine and five non-endocrine organ-specific autoimmune disorders were reported. In PAS III, two other autoimmune endocrinopathies, six non-endocrine organ-specific, and four systemic autoimmune disorders were found in combination with AITDs.

Conclusions

AITDs, T1DM and AD are the most common combinations in PAS, thus screening for these conditions seems to be reasonable.

中文翻译：

在II型和III型多腺自身免疫综合症中，其他自身免疫疾病的患病率。

目的

多腺体自身免疫综合症（PAS）是复杂的异质性疾病，其中可能发生各种自身免疫性疾病，从而影响内分泌和非内分泌器官。在这项荟萃分析中，在PAS II和III中研究了相关的自身免疫性疾病的患病率。

方法

在MEDLINE和Embase数据库中的全面搜索确定了479项使用PAS II和PAS III关键字的研究。总共18份记录（总共1312例患者）符合我们的纳入标准（原始研究报道了至少10例病例，并且包含其他自身免疫性疾病的组合），并被选择进行进一步分析。使用随机效应模型进行了患病率的荟萃分析，并计算了95％的置信区间（CI）。每个荟萃分析的结果均使用森林图以图形方式显示。

结果

PAS II和PAS III区分了842例，其中PAS II和III分别为177和665（21.1 vs 78.9％）。桥本甲状腺炎的患病率明显高于Graves病（分别为39％[95％CI 17–65％]与4％[95％CI 0-10％]；p = 0.001）。在PAS II中，分别在65％，18％和10％的病例中，艾迪生氏病（AD）与AITD，T1DM或这些疾病的组合并存。此外，还报告了另一种内分泌疾病和五种非内分泌器官特异性自身免疫疾病。在PAS III中，与AITD联合发现了另外两种自身免疫性内分泌病，六种非内分泌器官特异性和四种全身性自身免疫性疾病。