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Status and Future Scope of Hydrogels in Wound Healing: Synthesis, Materials and Evaluation
European Polymer Journal ( IF 6 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.eurpolymj.2020.109609
Jinxi Xiang , Lan Shen , Yanlong Hong

Abstract The hydrogel wound dressing is an ideal wound treatment because of its excellent biocompatibility, high moisture resistance and the ability to activate immune cells to speed wound healing. However, the biomedical applications of hydrogels are limited currently, due to their poor mechanical properties and insufficient adhesion. In order to expand the scope of its application, people have explored new methods of chemical and physical cross-linking, designed new composite hydrogels, and introduced effective energy dissipation mechanisms. In this review, we also discuss materials used to produce hydrogels, focused on TCM-based hydrogel materials with bioactive properties that promote healing. Moreover, methods for evaluating hydrogel wound dressings are discussed to guide the preparation of new hydrogels.

中文翻译:

水凝胶在伤口愈合中的现状和未来范围:合成、材料和评估

摘要 水凝胶伤口敷料具有良好的生物相容性、高防潮性和激活免疫细胞加速伤口愈合的能力,是一种理想的伤口治疗方法。然而,由于其机械性能差和粘附力不足,目前水凝胶的生物医学应用受到限制。为了扩大其应用范围,人们探索了化学和物理交联的新方法,设计了新型复合水凝胶,并引入了有效的能量耗散机制。在这篇综述中,我们还讨论了用于生产水凝胶的材料,重点是具有促进愈合的生物活性特性的基于中药的水凝胶材料。此外,还讨论了评估水凝胶伤口敷料的方法,以指导新水凝胶的制备。
更新日期:2020-05-01
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