当前位置: X-MOL 学术Eur. Polym. J. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Cross-linked PMS/PLA Nanofibers with Tunable Mechanical Properties and Degradation Rate for Biomedical Applications
European Polymer Journal ( IF 6 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.eurpolymj.2020.109633
Mahya Rahmani , Reza Faridi-Majidi , Mohammad-Mehdi Khani , Alireza Mashaghi , Farsad Noorizadeh , Hossein Ghanbari

Abstract Polymeric nanofibers have attracted research attention in recent years for various biomedical applications, including tissue engineering and regenerative medicine. In this work, a series of novel nanofibers based on PMS/PLA with different polymeric weight ratios of 3:2, 1:1, and 2:3 were successfully fabricated by the electrospinning technique. The resultant nanofibers were then cross-linked using high-temperature vacuum oven and sterilized via various methods. The mechanical properties such as elasticity and stiffness, degradation behavior, and cytocompatibility were studied in order to investigate the potential of PMS/PLA nanofibers for tissue engineering applications. The results revealed that by increasing the cross-linking temperature up to 90 °C, PMS/PLA nanofibers maintained their nanostructured features even though there were slight changes in the morphology and diameters of the fibers. The average ultimate tensile stress (σUTS) and Young modulus (E) of the PMS/PLA nanofibers significantly increased with cross-linking temperatures ranging from 2.51 to 3.88 MPa to 6.08–11.07 MPa and from 47.88 to 57.10 MPa to 101.37–142.31 MPa, respectively. The degradation rate of PMS/PLA nanofibers significantly decreased after the cross-linking process. The results also revealed that cross-linked PMS/PLA nanofibers could be safely sterilized without severe damages to fibrous microstructures. The PMS/PLA nanofibers revealed no significant cellular toxicity in in vitro cell culture models. The outcomes suggest that PMS/PLA nanofibers could be effectively fabricated with a range of mechanical properties and degradation rates for tissue engineering applications.

中文翻译:

用于生物医学应用的具有可调机械性能和降解率的交联 PMS/PLA 纳米纤维

摘要 近年来,聚合物纳米纤维在包括组织工程和再生医学在内的各种生物医学应用中引起了研究的关注。在这项工作中,通过静电纺丝技术成功制备了一系列基于 PMS/PLA 的具有 3:2、1:1 和 2:3 不同聚合物重量比的新型纳米纤维。然后使用高温真空烘箱将所得纳米纤维交联并通过各种方法进行消毒。研究了弹性和刚度、降解行为和细胞相容性等机械性能,以研究 PMS/PLA 纳米纤维在组织工程应用中的潜力。结果表明,通过将交联温度提高至 90 °C,即使纤维的形态和直径略有变化,PMS/PLA 纳米纤维仍保持其纳米结构特征。PMS/PLA 纳米纤维的平均极限拉伸应力 (σUTS) 和杨氏模量 (E) 随着交联温度范围从 2.51 到 3.88 MPa 到 6.08–11.07 MPa 和从 47.88 到 57.10 MPa 到 101.37–142.31 MPa 显着增加,分别。交联过程后 PMS/PLA 纳米纤维的降解率显着降低。结果还表明,交联的 PMS/PLA 纳米纤维可以安全灭菌,而不会严重损坏纤维微结构。PMS/PLA 纳米纤维在体外细胞培养模型中没有显示出显着的细胞毒性。
更新日期:2020-05-01
down
wechat
bug