Beginning with the discovery more than 35 years ago that oxygen chemoreceptors of the fish gill are enriched with serotonin, numerous studies have examined the importance of this, and other neuroendocrine factors in piscine chemoreceptor function, and in particular on the chemoreceptor-mediated reflex control of breathing. However, despite these studies, there is continued debate as to the role of neuroendocrine factors in the initiation or modulation of breathing during environmental disturbances or physical activity. In this review, we summarize the state-of-knowledge surrounding the neuroendocrine control of oxygen chemoreception in fish and the associated reflex adjustments to ventilation. We focus on neurohumoral substances that either are present in chemosensory cells or those that are localised elsewhere but have also been implicated in the direct control of breathing. These substances include serotonin, catecholamines (adrenaline and noradrenaline), acetylcholine, purines and gaseous neurotransmitters. Despite the growing indirect evidence for an involvement of these neuroendocrine factors in chemoreception and ventilatory control, direct evidence awaits the incorporation of novel methods currently under development.

中文翻译：

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鱼的呼吸的神经内分泌控制。

从35年前发现鱼that的氧化学感受器富含5-羟色胺开始，许多研究已经检查了这一点，以及其他神经内分泌因素在鱼类化学感受器功能中的重要性，特别是在化学感受器介导的反射控制方面呼吸。然而，尽管进行了这些研究，但是关于神经内分泌因子在环境扰动或身体活动过程中呼吸的启动或调节中的作用仍存在争议。在这篇综述中，我们总结了围绕鱼类氧化学感受的神经内分泌控制以及对通气的相关反射调节的知识状态。我们专注于存在于化学感觉细胞中或位于其他地方但又与呼吸的直接控制有关的神经体液物质。这些物质包括5-羟色胺，儿茶酚胺（肾上腺素和去甲肾上腺素），乙酰胆碱，嘌呤和气态神经递质。尽管越来越多的间接证据表明这些神经内分泌因子参与化学感受和通气控制，但直接证据正在等待目前正在开发的新方法的纳入。