Intracellular pathogens have evolved numerous strategies to manipulate their host cells to survive and replicate in a hostile environment. They often exploit membrane trafficking pathways to enter the cell, establish a replicative niche, avoid degradation and immune response, acquire nutrients and lastly, egress. Recent studies on membrane trafficking exploitation by intracellular pathogens have led to the discovery of novel and fascinating cell biology, including a noncanonical mechanism of ubiquitination and a novel mitophagy receptor. Thus, studying how pathogens target host cell membrane trafficking pathways is not only important for the development of new therapeutics, but also helps understanding fundamental mechanisms of cell biology.

中文翻译：

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“让路”：膜交通的病原体开发。

细胞内病原体已经进化出许多策略来操纵它们的宿主细胞在恶劣的环境中生存和复制。它们经常利用膜运输途径进入细胞，建立复制生态位，避免降解和免疫反应，获取营养，最后离开。最近对细胞内病原体对膜运输利用的研究导致了新的和迷人的细胞生物学的发现，包括泛素化的非经典机制和新的线粒体自噬受体。因此，研究病原体如何靶向宿主细胞膜运输途径不仅对开发新疗法很重要，而且有助于理解细胞生物学的基本机制。