Highlights • Detailed RILD evolution described by objective radiological and pulmonary function measures.• RILD is associated with volume loss of the treated lung and contralateral lung hyperinflation.• Objective radiological findings might differentiate subjects with early versus late RILD.• Most patients developed progressive lung damage, even when the early phase is absent/mild.• Pre-RT lung function and RT dosimetry may identify subjects at increased risk of developing RILD.

中文翻译：

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使用连续 CT 成像和肺功能测试研究辐射引起的肺损伤的演变

亮点 • 由客观放射学和肺功能测量描述的详细 RILD 演变。• RILD 与治疗肺容量减少和对侧肺过度充气有关。• 客观放射学发现可能区分早期和晚期 RILD 受试者。• 大多数患者发展为进行性肺损伤，即使早期阶段不存在/轻度。• 放疗前肺功能和放疗剂量测定可能会识别出患 RILD 风险增加的受试者。